PU-WS13 - CAS 1454619-14-7
Catalog number: 1454619-14-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H20Cl2N6S
Molecular Weight:
411.35
COA:
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Targets:
Hsp90 | HSP
Description:
PU-WS13 is a cell-permeable inhibitor of Grp94 (EC50 = 220 nM).It shows selectivity for Grp94 over the related Hsps Trap-1, Hsp90α, and Hsp90β. PU-WS13 blocks the proliferation of HER2 over-expressing SK-BR-3 cells in the sub-G1 phase and induces apoptosis, but does not affect the survival of normal cells significantly.It induces both necrosis and apoptosis in multiple myeloma cells but does not induce death in pre-B leukemic cells. Unlike pan-Hsp90 inhibitors, PU-WS13 inactivate a feedback heat-shock response.
Brife Description:
PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
Solubility:
DMSO: 40mg/mL
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Application:
PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective Hsp90 inhibitors used in anti-tumor treatments.
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
JYSLFQTWNRYWJT-UHFFFAOYSA-N
InChI:
InChI=1S/C17H20Cl2N6S/c1-10(2)21-4-3-5-25-16-14(15(20)22-9-23-16)24-17(25)26-13-7-11(18)6-12(19)8-13/h6-10,21H,3-5H2,1-2H3,(H2,20,22,23)
Canonical SMILES:
CC(C)NCCCN1C2=C(C(=NC=N2)N)N=C1SC3=CC(=CC(=C3)Cl)Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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Chemical Structure

CAS 1454619-14-7 PU-WS13

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