PS 47 - CAS 1180676-33-8
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
PS 47 is an inactive E-isomer of the PDK1 activator PS 48. In combination with PS 48, PS 47 can be used as a negative control.
Brife Description:
PDK1 negative activator
PS-47; PS 47; PS47; (E)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid
Canonical SMILES:
1.Microphase Separation within Disk Shaped Aggregates of Triblock Bottlebrushes.
Long M;Shi Y;Zhang K;Chen Y Macromol Rapid Commun. 2016 Apr;37(7):605-9. doi: 10.1002/marc.201500686. Epub 2016 Feb 11.
Well-defined AbBA triblock bottlebrush with poly(N,N-dimethyl acrylamide) (PAm) as A block and polyacrylate, densely grafted with poly(tert-butyl acrylate)-block-polystyrene (PBA-b-PS), as brush bB block is prepared by controlled radical polymerization and click chemistry. The triblock copolymer with a composition of PAm200 -b-b(PBA14 -b-PS47 )167 -b-PAm200 is obtained and is further transformed into PAm200 -b-b(PAA14 -b-PS47 )167 -b-PAm200 by hydrolysis of the PBA segment into poly(acrylic acid) (PAA). In a mixture of N,N-dimethylformamide (DMF) and methanol, a poor solvent of bB block, PAm200 -b-b(PAA14 -b-PS47 )167 -b-PAm200 self-assembled into disk-like platelets, which have an internal lamellar structure by further microphase-separation of PAA-b-PS branches in 2D. Moreover, Ag nanoparticles are aligned by PAA segments along the disk to form a pattern.
2.The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme.
Hettle AG;Vickers C;Robb CS;Liu F;Withers SG;Hehemann JH;Boraston AB Structure. 2018 May 1;26(5):747-758.e4. doi: 10.1016/j.str.2018.03.012. Epub 2018 Apr 19.
Sulfatases play a biologically important role by cleaving sulfate groups from molecules. They can be identified on the basis of signature sequences within their primary structures, and the largest family, S1, has predictable features that contribute specifically to the recognition and catalytic removal of sulfate groups. However, despite advances in the prediction and understanding of S1 sulfatases, a major question regards the molecular determinants that drive substrate recognition beyond the targeted sulfate group. Here, through analysis of an endo-4S-ι-carrageenan sulfatase (PsS1_19A) from Pseudoalteromonas sp. PS47, particularly X-ray crystal structures in complex with intact substrates, we show that specific recognition of the substrate leaving group components, in this case carbohydrate, provides the enzyme with specificity for its substrate. On the basis of these results we propose a catalytic subsite nomenclature that we anticipate will form a general foundation for understanding and describing the molecular basis of substrate recognition by sulfatases.
3.Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing.
Bæk KT;Frees D;Renzoni A;Barras C;Rodriguez N;Manzano C;Kelley WL PLoS One. 2013 Sep 30;8(9):e77122. doi: 10.1371/journal.pone.0077122. eCollection 2013.
Staphylococcus aureus strains of the 8325 lineage, especially 8325-4 and derivatives lacking prophage, have been used extensively for decades of research. We report herein the results of our deep sequence analysis of strain 8325-4. Assignment of sequence variants compared with the reference strain 8325 (NRS77/PS47) required correction of errors in the 8325 reference genome, and reassessment of variation previously attributed to chemical mutagenesis of the restriction-defective RN4220. Using an extensive strain pedigree analysis, we discovered that 8325-4 contains 16 single nucleotide polymorphisms (SNP) arising prior to the construction of RN4220. We identified 5 indels in 8325-4 compared with 8325. Three indels correspond to expected Φ11, 12, 13 excisions, one indel is explained by a sequence assembly artifact, and the final indel (Δ63bp) in the spa-sarS intergenic region is common to only a sub-lineage of 8325-4 strains including SH1000. This deletion was found to significantly decrease (75%) steady state sarS but not spa transcript levels in post-exponential phase. The sub-lineage 8325-4 was also found to harbor 4 additional SNPs. We also found large sequence variation between 8325, 8325-4 and RN4220 in a cluster of repetitive hypothetical proteins (SA0282 homologs) near the Ess secretion cluster.
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CAS 1180676-33-8 PS 47

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