Prucalopride Succinate - CAS 179474-85-2
Catalog number: B0084-470898
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
5-HT Receptor
Prucalopride, also known as R-108512, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-470898 200 mg $199 In stock
Bulk Inquiry
Related CAS:
179474-81-8 (Free base)
Solid powder
4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate; R-108512; R 108512; R108512; Prucalopride Succinate; Resolor; Resotran
Soluble in DMSO, not in water
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life:
2 years if stored properly
Canonical SMILES:
1.Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials.
Camilleri M1, Piessevaux H2, Yiannakou Y3, Tack J4, Kerstens R5, Quigley EM6, Ke M7, Da Silva S8, Levine A9. Dig Dis Sci. 2016 Apr 7. [Epub ahead of print]
BACKGROUND: Prucalopride, a selective, high-affinity 5-hydroxytryptamine 4 receptor agonist, stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation (CC) in adults. The relative efficacy by gender has not been evaluated.
2.Prucalopride Exerts Neuroprotection In Human Enteric Neurons.
Bianco F, Bonora E, Natarajan D, Vargiolu M, Thapar N1, Torresan F, Giancola F, Boschetti E, Volta U, Bazzoli F, Mazzoni M, Seri M, Clavenzani P, Stanghellini V2, Sternini C3, De Giorgio R4. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 18:ajpgi.00036.2016. doi: 10.1152/ajpgi.00036.2016. [Epub ahead of print]
BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT) and its transporters and receptors are involved in a wide array of digestive functions. In particular, 5-HT4 receptors are known to mediate intestinal peristalsis and recent data in experimental animals have shown their role in neuronal maintenance and neurogenesis. This study has been designed to test whether prucalopride, a well-known full 5-HT4 agonist, exerts protective effects on neurons, including enteric neurons, exposed to oxidative stress challenge.
3.Use of prucalopride for chronic constipation: a systematic review and meta-analysis of published randomized, controlled trials.
Sajid MS1, Hebbar M1, Baig MK1, Li A2, Philipose Z2. J Neurogastroenterol Motil. 2016 Apr 29. doi: 10.5056/jnm16004. [Epub ahead of print]
This article highlights the role of prucalopride in the management of chronic constipation based upon the principles of meta-analysis using data reported in the published randomized, controlled trials. Sixteen randomized, controlled trials on 3943 patients reported the effectiveness of prucalopride in patients with chronic constipation. Prucalopride successfully increased the frequency of spontaneous bowel movements per week in all variable doses of 1 mg (standardized mean difference, 0.42 [95% CI, 0.18-0.66; P = 0.006]), 2 mg (standardized mean difference, 0.34 [95% CI, 0.11-0.56; P = 0.003]), and 4 mg (standardized mean difference, 0.33 [95% CI, 0.22-0.44; P = 0.00001]). The risks of adverse events or side effects such as headache, abdominal cramps, excessive flatulence, dizziness, diarrhoea, and rash were higher (odds ratio, 1.70 [95% CI, 1.27 to -2.27; P = 0.0004]) in prucalopride group. Prucalopride is clinically a beneficial pharmacotherapy for chronic constipation and its routine use may be considered in patients with chronic simple laxative-resistant constipation.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products

CAS 103639-04-9 Ondansetron Hydrochloride Dihydrate

Ondansetron Hydrochloride Dihydrate
(CAS: 103639-04-9)

Ondansetron hydrochloride dihydrate is a specific and competitive antagonist of serotonin 5-HT3 receptor (Ki = 0.77 nM) with anxiolytic and neuroleptic activiti...

CAS 167710-87-4 RS 39604 hydrochloride

RS 39604 hydrochloride
(CAS: 167710-87-4)

RS 39604 is a high affinity and selective 5-HT4 receptor antagonist that is orally active and long-lasting in vivo, with a pKi of 9.1 at 5-HT4 receptors in guin...

CAS 350992-13-1 Bifeprunox mesylate

Bifeprunox mesylate
(CAS: 350992-13-1)

Bifeprunox mesylate is a dopamine D2 and 5-HT1A partial agonist developed as an atypical antipsychotic for the treatment of schizophrenia and other psychotic in...

CAS 1451210-48-2 8-Hydroxy-PIPAT oxalate

8-Hydroxy-PIPAT oxalate
(CAS: 1451210-48-2)

8-Hydroxy-PIPAT oxalate is a high affinity 5-HT1A receptor agonist (Kd = 0.38 nM) that has the potential for the treatment of disorders of serotonin release.

CAS 845861-39-4 CP 94253 hydrochloride

CP 94253 hydrochloride
(CAS: 845861-39-4)

The hydrochloride salt form of CP 94253, which is a 5-HT1B agonist and exhibit anticonvulsant activities.

CAS 199864-87-4 RS 127445

RS 127445
(CAS: 199864-87-4)

RS 127445 is a high affinity, orally bioavailable, selective serotonin antagonist of 5-HT2B receptor (pIC50= 10.4) with 1000 fold selectivity over the human rec...

6-Hydroxybuspirone hydrochloride

A major active metabolite of Buspirone, a 5-HT1A partial agonist, with higher bioavailability than that of buspirone.

CAS 122852-43-1 Alosetron (Z)-2-butenedioate

Alosetron (Z)-2-butenedioate
(CAS: 122852-43-1)

The maleic acid salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome.

Chemical Structure

CAS 179474-85-2 Prucalopride Succinate

Quick Inquiry

Verification code

Featured Items