Prucalopride Succinate - CAS 179474-85-2
Catalog number: B0084-470898
Category: Inhibitor
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Molecular Formula:
C22H32ClN3O7
Molecular Weight:
485.96
COA:
Inquire
Targets:
5-HT Receptor
Description:
Prucalopride, also known as R-108512, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-470898 200 mg $199 In stock
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Purity:
98%
Related CAS:
179474-81-8 (Free base)
Appearance:
Solid powder
Synonyms:
4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate; R-108512; R 108512; R108512; Prucalopride Succinate; Resolor; Resotran
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
Canonical SMILES:
O=C(O)CCC(O)=O.O=C(C1=C(OCC2)C2=C(N)C(Cl)=C1)NC3CCN(CCCOC)CC3
1.Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials.
Camilleri M1, Piessevaux H2, Yiannakou Y3, Tack J4, Kerstens R5, Quigley EM6, Ke M7, Da Silva S8, Levine A9. Dig Dis Sci. 2016 Apr 7. [Epub ahead of print]
BACKGROUND: Prucalopride, a selective, high-affinity 5-hydroxytryptamine 4 receptor agonist, stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation (CC) in adults. The relative efficacy by gender has not been evaluated.
2.Prucalopride Exerts Neuroprotection In Human Enteric Neurons.
Bianco F, Bonora E, Natarajan D, Vargiolu M, Thapar N1, Torresan F, Giancola F, Boschetti E, Volta U, Bazzoli F, Mazzoni M, Seri M, Clavenzani P, Stanghellini V2, Sternini C3, De Giorgio R4. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 18:ajpgi.00036.2016. doi: 10.1152/ajpgi.00036.2016. [Epub ahead of print]
BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT) and its transporters and receptors are involved in a wide array of digestive functions. In particular, 5-HT4 receptors are known to mediate intestinal peristalsis and recent data in experimental animals have shown their role in neuronal maintenance and neurogenesis. This study has been designed to test whether prucalopride, a well-known full 5-HT4 agonist, exerts protective effects on neurons, including enteric neurons, exposed to oxidative stress challenge.
3.Use of prucalopride for chronic constipation: a systematic review and meta-analysis of published randomized, controlled trials.
Sajid MS1, Hebbar M1, Baig MK1, Li A2, Philipose Z2. J Neurogastroenterol Motil. 2016 Apr 29. doi: 10.5056/jnm16004. [Epub ahead of print]
This article highlights the role of prucalopride in the management of chronic constipation based upon the principles of meta-analysis using data reported in the published randomized, controlled trials. Sixteen randomized, controlled trials on 3943 patients reported the effectiveness of prucalopride in patients with chronic constipation. Prucalopride successfully increased the frequency of spontaneous bowel movements per week in all variable doses of 1 mg (standardized mean difference, 0.42 [95% CI, 0.18-0.66; P = 0.006]), 2 mg (standardized mean difference, 0.34 [95% CI, 0.11-0.56; P = 0.003]), and 4 mg (standardized mean difference, 0.33 [95% CI, 0.22-0.44; P = 0.00001]). The risks of adverse events or side effects such as headache, abdominal cramps, excessive flatulence, dizziness, diarrhoea, and rash were higher (odds ratio, 1.70 [95% CI, 1.27 to -2.27; P = 0.0004]) in prucalopride group. Prucalopride is clinically a beneficial pharmacotherapy for chronic constipation and its routine use may be considered in patients with chronic simple laxative-resistant constipation.
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CAS 179474-85-2 Prucalopride Succinate

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