Propylene glycol caprylate - CAS 31565-12-5
Molecular Formula:
C11H24O4
Molecular Weight:
220.31
COA:
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Description:
Propylene glycol caprylate is a surfactant used as an emulsifier.
MSDS:
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1.Pharmacokinetic behaviour of sublingually administered 8-methoxypsoralen for PUVA therapy.
Shephard SE1, Langguth P, Panizzon RG. Photodermatol Photoimmunol Photomed. 2001 Feb;17(1):11-21.
BACKGROUND: Conventional oral PUVA therapy is hampered by large inter- and intraindividual variations in the bioavailability of 8-methoxypsoralen (8-MOP), caused by its low solubility in the gastrointestinal juices and large interindividual differences in hepatic metabolism rate (hepatic first pass).
2.Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin.
Takahashi K1, Sakano H, Yoshida M, Numata N, Mizuno N. J Control Release. 2001 Jun 15;73(2-3):351-8.
In this study, we investigated the effect of sefsols on the skin to clarify the mechanism of the sefsol enhancement effect. In vitro percutaneous absorption experiments were performed using Franz diffusion cells. Removal of the stratum corneum and delipidization of the skin increased the permeation of diclofenac from aqueous suspension, with the enhancement effects being similar for both treatments. Further enhancement effects of diclofenac permeation by sefsol through the stripped and delipidized skin were not observed. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) was employed to investigate the biophysical changes in the stratum corneum lipids by sefsols. One of the sefsols, propylene glycol mono caprylate (S-218), induced higher and broader absorbance shifts in both asymmetric and symmetric C-H bond stretching regions. However, no significant differences were observed among the sefsols with respect to peak heights and areas for both absorbances when compared with H2O treatment.
3.Development of the ambroxol gels for enhanced transdermal delivery.
Cho CW1, Choi JS, Shin SC. Drug Dev Ind Pharm. 2008 Mar;34(3):330-5. doi: 10.1080/03639040701662644 .
Ambroxol is an expectoration improver and mucolytic agent that has been used to treat acute and chronic disorders. However, ambroxol needs to be administered percutaneously in order to avoid systemic adverse effects, such as headache, drowsiness, dizziness, and insomnia, which can occur after oral administration. The aim of this study was to develop a gel preparation containing a permeation enhancer to enhance the delivery of ambroxol. The ambroxol gels were prepared using hydroxypropyl methylcellulose (HPMC) and poloxamer 407. The release characteristics of the drug from the gels were examined according to the receptor medium, drug concentration, and temperature. The rate of drug permeation into the skin was enhanced by incorporating various enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants, and the fatty acids into the gels. The permeation study through mouse skin was examined at 37 C.
4.Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers.
Brayden D1, Creed E, O'Connell A, Leipold H, Agarwal R, Leone-Bay A. Pharm Res. 1997 Dec;14(12):1772-9.
PURPOSE: The effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) on heparin intestinal absorption were studied using rat in situ ileal and colonic instillations and Caco-2 monolayers.
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Chemical Structure

CAS 31565-12-5 Propylene glycol caprylate

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