Prexasertib mesylate - CAS 1234015-55-4
Category: Inhibitor
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Molecular Formula:
C19H23N7O5S
Molecular Weight:
461.49
COA:
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Targets:
Checkpoint Kinase (Chk)
Description:
Prexasertib, also known as LY2606368, is an ATP-competitive CHK1 inhibitor (Ki= 0.9 nmol/L), with minor activity against CHK2 and RSK with IC50= 8 nM and 9 nM respectively in cell-free assay. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
Related CAS:
1234015-54-3 (2HCl)
Appearance:
Yellow solid powder
Synonyms:
2-Pyrazinecarbonitrile, 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)-, methanesulfonate; Prexasertib mesylate; LY2606368; LY-2606368; LY 2606368.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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InChIKey:
WGCKOJKXQKKLQW-UHFFFAOYSA-N
InChI:
1S/C18H19N7O2.CH4O3S/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;1-5(2,3)4/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);1H3,(H,2,3,4)
Canonical SMILES:
N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O
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Chemical Structure

CAS 1234015-55-4 Prexasertib mesylate

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