|Targets||Checkpoint Kinase (Chk)|
|Description||Prexasertib, also known as LY2606368, is an ATP-competitive CHK1 inhibitor (Ki= 0.9 nmol/L), with minor activity against CHK2 and RSK with IC50= 8 nM and 9 nM respectively in cell-free assay. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.|
|Related CAS||1234015-54-3 (2HCl)|
|Appearance||Yellow solid powder|
|Synonyms||2-Pyrazinecarbonitrile, 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)-, methanesulfonate; Prexasertib mesylate; LY2606368; LY-2606368; LY 2606368.|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase.
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