|Description||Pregnanolone, also known as Kabi-2213, SKF 6455, Eltanolone, is a GABAA receptor positive allosteric modulator potentially for the treatment of pain.|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
Thiocolchicoside is a semi-synthetic derivative of colchicine, an anti-inflammatory glycoside extracted from the flower seeds of superba gloriosa. Thiocolchicos...
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
Guvacine hydrochloride is a specific GABA uptake inhibitor (IC50 = 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). Guvacine may be...
Saclofen is a selective antagonist at GABAB receptors.
Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodiazepine class. It exhibits anxioly...
FGIN-1-43 is a potent and specific ligand for the mitochondial DBI receptor (MDR).
FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 i...
(-)-Bicuculline methiodide is the methiodide salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors.
Ro 19-4603 is a novel potent partial inverse agonist of benzodiazepine (BZ) receptors. Ro19-4603 binds with high affinity to both diazepam-sensitive (DS) and di...
β-CCB is an endogenous benzodiazepine binding inhibitor with proconvulsant and anxiogenic properties.
(±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hG...
MK 0343, also known as MRK-409, is a subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively). MK-03...
Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions.
N-ArachidonylGABA is first isolated from bovine brain. It was also found to inhibit normal responses to pain in vivo, but has not been fully characterized to da...
PWZ-029, a benzodiazepine derivative, has been found to be a GABAA receptors inverse agonist that could probably improve memory and exhibit sedative effects at ...
(R)-baclofen a selective GABAB agonist.
Etifoxine Hydrochloride is Potentiator of GABAA receptor with anxiolytic and anticonvulsant activity.
CGP 54626 hydrochloride
The hydrochloride salt form of CGP 54626, a dichloropheny derivative, has been found to be a GABAB receptor antagonist that could probably be effective as an an...
Isoguvacine hydrochloride is a selective GABA receptor agonist with anticonvulsant and antiepileptic effect, developed for Neuroscience research.
(S)-(-)-4-Amino-2-hydroxybutyric acid is an analogue of γ-aminobutyric acid (GABA) that exhibits potential inhibitory activity on GABA binding and uptake by bra...