Prednisolone - CAS 50-24-8
Catalog number: 50-24-8
Category: APIs
Molecular Formula:
Molecular Weight:
White or off-white crystalline powder
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1. Stability-indicating HPLC-DAD method for the simultaneous determination of fluoroquinolones and corticosteroids in ophthalmic formulations
Rubia Adrieli Sversut, Marcos Serrou do Amaral, Najla Mohamad Kassab*. Anal. Methods,2014, 6,2125–2133
A stability-indicating HPLC-DAD method was developed and validated for simultaneous determination of two ophthalmic combinations of a fluoroquinolone and a corticosteroid, viz.,gatifloxacin and prednisolone acetate or ciprofloxacin hydrochloride and dexamethasone. This method shows specificity, precision, accuracy, sensitivity, and robustness for the assay of the fluoroquinolone and corticosteroid in ophthalmic formulations. In addition, the method was successfully applied to separate the active pharmaceutical ingredients from their forced degradation products. The results presented suggest that the proposed method can be used in routine quality-control analysis. The optimized chromatographic conditions can contribute to minimize organic solvent waste.
2. Biocomposites for wound-healing based on sol-gel magnetite
Andrey S. Drozdov, Katerina V. Volodina, Vasiliy V. Vinogradov and Vladimir V. Vinogradov*. RSC Adv., 2015, 5, 82992–82997
Magnetite coating is a mechanical and physiological barrier preventing the spread of germs from the wound into the surrounding tissue and absorbing toxic products of tissue decay, bacteria and toxins. Subsequently, granulation magnetite tissue turns into scar connective tissue, which is covered by epithelium on the outside. In order to neutralize the inflammatory processes, thereby reducing the size of scar tissue, prednisolone gradually releases. Prednisolone suppresses functionality of tissue macrophages, restricts the migration of leukocytes to the inflammation area, and contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the inflammation area. All of these processes take place against the background of inflammation, and are accompanied by suppuration arising from infection of the wound.
3. Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery
Giorgia D’Arrigo, Chiara Di Meo, Pietro Matricardi*. Soft Matter, 2012, 8, 11557–11564
In the present investigation, the prednisolone moiety, linked to the polymer chains by means of a short hydrocarbon chain, simultaneously acts as a pharmacological agent and a promoter of NH formation whereas cholesterol was chosen as a moiety able to promote the formation of reference NHs with no pharmacological activity. This approach allows us to combine the advantages of nanotechnology, such as high stability, high carrier capacity, and feasibility of different routes of administration with an immobilized form of prednisolone that displays improved bioavailability, thus increasing its therapeutic effects and reducing its dosing frequency.
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CAS 50-24-8 Prednisolone

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