Prednisolone Acetate - CAS 52-21-1
Catalog number: 52-21-1
Category: Inhibitor
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Molecular Formula:
C23H30O6
Molecular Weight:
402.48
COA:
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Targets:
Others
Description:
Prednisolone Acetate is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
Purity:
>98%
Synonyms:
Omnipred
MSDS:
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InChIKey:
LRJOMUJRLNCICJ-JZYPGELDSA-N
InChI:
InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
Canonical SMILES:
CC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)O
1.Effect of topical ketorolac 0.4%, nepafenac 0.1%, and bromfenac 0.09% on postoperative inflammation using laser flare photometry in patients having phacoemulsification.
Sahu S1, Ram J2, Bansal R1, Pandav SS1, Gupta A1. J Cataract Refract Surg. 2015 Oct;41(10):2043-8. doi: 10.1016/j.jcrs.2015.10.061.
PURPOSE: To study the effect of topical ketorolac 0.4% (Acular LS), bromfenac 0.09% (Megabrom), and nepafenac 0.1% (Nevanac) on postoperative inflammation using laser flare photometry in patients having phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation.
2.Effect of Polyethylene Glycol on Properties and Drug Encapsulation-Release Performance of Biodegradable/Cytocompatible Agarose-Polyethylene Glycol-Polycaprolactone Amphiphilic Co-Network Gels.
Chandel AK1, Kumar CU1, Jewrajka SK1. ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3182-92. doi: 10.1021/acsami.5b10675. Epub 2016 Jan 27.
We synthesized agarose-polycaprolactone (Agr-PCL) bicomponent and Agr-polyethylene glycol-PCL (Agr-PEG-PCL) tricomponent amphiphilic co-network (APCN) gels by the sequential nucleophilic substitution reaction between amine-functionalized Agr and activated halide terminated PCL or PCL-b-PEG-b-PCL copolymer for the sustained and localized delivery of hydrophilic and hydrophobic drugs. The biodegradability of the APCNs was confirmed using lipase and by hydrolytic degradation. These APCN gels displayed good cytocompatibility and blood compatibility. Importantly, these APCN gels exhibited remarkably high drug loading capacity coupled with sustained and triggered release of both hydrophilic and hydrophobic drugs. PEG in the APCNs lowered the degree of phase separation and enhanced the mechanical property of the APCN gels. The drug loading capacity and the release kinetics were also strongly influenced by the presence of PEG, the nature of release medium, and the nature of the drug.
3.Effect of onion extract on corneal haze suppression after air assisted lamellar keratectomy.
Kim S1, Park YW, Lee E, Park SW, Park S, Noh H, Kim JW, Seong JK, Seo K. J Vet Med Sci. 2016 Apr 1;78(3):419-25. doi: 10.1292/jvms.15-0455. Epub 2015 Nov 26.
This study evaluated the effect of onion extract on corneal haze suppression after applying the air assisted lamellar keratectomy. The air assisted lamellar keratectomy was performed on 24 canine eyes. They were treated with an artificial tear (group C), prednisolone acetate (group P), onion extract (group O) and TGF-β1 (group T) three times per day from 7 to 28 days after the surgery. Corneal haze occurred on the all eyes and was observed beginning 7 days after the surgery. The haze was significantly decreased in groups P and O from day 14 compared with the group C using the clinical (group P; P=0.021, group O; P=0.037) and objective evaluation method (group P; P=0.021, group O; P=0.039). In contrast, it was significantly increased in group T from day 14 compared with group C based on the clinical (P=0.002) and objective evaluation method (P<0.001). Subsequently, these eyes were enucleated after euthanasia, and immunohistochemistry with α-SMA antibodies was done.
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CAS 52-21-1 Prednisolone Acetate

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