|Targets||HMG-CoA Reductase (HMGCR)|
|Description||Pravastatin is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase with IC50 of 5.6 μM. It is used in combination with diet, exercise, and weight loss for lowering cholesterol and preventing cardiovascular disease. It is a synthetic lipid-lowering agent. It lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. It is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.|
|Appearance||White to yellowish white powder or crystalline powder|
|Synonyms||1-Naphthaleneheptanoicacid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-,[1S-[1a(bS*,dS*),2a,6a,8b(R*),8aa]]-;3b-Hydroxycompactin;Eptastatin;Mevalothin;Pravastatin acid;Pravachol; Pravastatina;Pravastatine;Pravastatinum;(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid|
|Solubility||10 mM in H2O (free soluble)|
|Application||Pravastatin acts as a competitive inhibitor of HMG CoA reductase. It is a synthetic lipid-lowering agent. It is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||634.5±55.0 °C | Condition: Press: 760 Torr|
|Melting Point||171.2-173 °C|
|Density||1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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