Pramipexole dihydrochloride monohydrate - CAS 191217-81-9
Catalog number: B0084-061932
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Dopamine Receptor
Pramipexole is a dopamine agonist with Ki values of 3.9, 2.2, 0.5, 5.1 nM for D2S, D2L, D3 and D4 receptors respectively. It has been used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-061932 5 g $198 In stock
Bulk Inquiry
Pramipexole Dihydrochloride Monohydrate; Pramipexole Dihydrochloride; Pramipexole 2HCl Monohydrate; Pramipexole 2HCl H2O;
Canonical SMILES:
1. A novel and simple electrochemical sensor for some dopaminergic drugs such as selegiline and pramipexole based on a nickel nanoparticle modified carbon paste electrode
Reza Ojani,* Shahab Gholitabar Omrani, Jahan-Bakhsh Raoof and Saeed Zamani. Anal. Methods,2016, 8,2471–2478
Electrocatalytic determination of selegiline andpramipexole. Since cyclic voltammetry is not sensitive for low concentrations of SEL and PX. In order to enhance the sensitivity of the method, constant potential amperometry under hydrodynamic conditions was used to detect the lower concentrations of SEL and PX. Fig. 8 shows a typical hydrodynamic amperometric response obtained by adding SEL to a continuously stirred 100 mV NaOH solution, which shows an increase in the current for successive increments of 5 mM SEL. The inset of Fig. 10 illustrates the corresponding plot showing a linear relationship between the peak current and the SEL concentrations. This modified electrode exhibited similar concentration dependent profiles for PX. The analytical parameters are listed in Table 1. The applicability of the proposed amperometricmethod was examined by analyzing the plasma sample. The recovery of SEL and PX was measured by spiking SEL and PX into highly diluted plasma samples and the standard addition method was used to analyze the prepared samples. The quantity experimentally determined was compared to that of the spiking in plasma samples. The results are summarized in Table 2. Typical examples of amperograms are shown in Fig. 9.
2. A novel electrochemical sensor for non-ergoline dopamine agonist pramipexole based on electrochemically reduced graphene oxide nanoribbons
Prashanth S. Narayana, Nagappa L. Teradal, J. Seetharamappa* and Ashis K. Satpati. Anal. Methods,2015, 7,3912–3919
Pramipexole (PPX), chemically known as (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, is an orally active, non-ergoline, azepine derivative. It is a dopamineagonist used for the treatment of restless legs syndrome and Parkinson's disease. PPX is a novel aminobenzothiazole compound having the highest affinity towards D3-subtype dopamine receptors. PPX has an excellent oral bioavailability. Food does not influence the degree of absorption. A literature survey revealed that only one voltammetric method was reported for the assay of Pramipexole (PPX). However, the reported voltammetric method uses bismuth for electrode modification. Bismuth is known to cause kidney damage and other health risks and so its extensive use is not recommended. Moreover, the reported method is less sensitive (LOD=12.79 ng mL-1) and needs longer time for drying themodified electrode at room temperature. In view of this, we have used graphene oxide nanoribbons for the modification of the electrode and adapted an eco-friendly method for its reduction. The purpose of the present investigation is to develop an environmentally friendly, simple, sensitive and economically feasible sensor for the determination of Pramipexole (PPX) in tablets, human plasma and urine samples.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products

CAS 91374-20-8 Ropinirole HCl

Ropinirole HCl
(CAS: 91374-20-8)

Ropinirole a selective D-2 agonist with Ki of 29 nM.

CAS 314-19-2 (R)-(-)-Apomorphine hydrochloride

(R)-(-)-Apomorphine hydrochloride
(CAS: 314-19-2)

(R)-(-)-Apomorphine hydrochloride is the hydrochloride salt of apomorphine, which is a prototypical non-selective dopamine D2 agonist. It exhibits pKi values of...

CAS 104632-27-1 Pramipexole impurity D

Pramipexole impurity D
(CAS: 104632-27-1)

The dihydrochloride salt form of dexpramipexole, also known as R-(+)-Pramipexole, is one of the impurities of pramipexole. It coule be used as a negative contro...

CAS 1217473-50-1 (+)-UH 232 maleate

(+)-UH 232 maleate
(CAS: 1217473-50-1)

(+)-UH 232 maleate is a dopamine D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay) that preferentially ...

CAS 62421-17-4 TL 232 hydrobromide

TL 232 hydrobromide
(CAS: 62421-17-4)

TL 232 hydrobromide is a dopamine receptor agonist.

ST-836 hydrochloride
(CAS: 1415564-68-9)

ST-836 hydrochloride, the hydrochloride salt form of verubulin, a dopamine receptor ligand that antiparkinsonian effect.

CAS 15622-65-8 Molindone hydrochloride

Molindone hydrochloride
(CAS: 15622-65-8)

Molindone hydrochloride, an indole derivative, as an antipsychotic agent it blocks the effects of dopamine in the brain which can be used for the treatment of s...

CAS 67383-44-2 RU 24213

RU 24213
(CAS: 67383-44-2)

RU 24213 is a dopamine D2 receptor agonist as well as a kappa opioid receptor antagonist.

Chemical Structure

CAS 191217-81-9 Pramipexole dihydrochloride monohydrate

Quick Inquiry

Verification code

Featured Items