Polydextrose - CAS 68424-04-4
Category: Carbohydrates
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1.Cow's milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT.
Pontes MV1, Ribeiro TC2, Ribeiro H3, de Mattos AP4, Almeida IR5, Leal VM6, Cabral GN7, Stolz S8, Zhuang W9, Scalabrin DM10. Nutr J. 2016 Feb 27;15(1):19. doi: 10.1186/s12937-016-0138-0.
BACKGROUND: Nutrients such as docosahexaenoic acid (DHA), prebiotics and β-glucan have been associated with reduced incidence of respiratory illnesses and allergic manifestations (AM). Our objective was to assess if consumption of a cow's milk-based beverage with these and other nutrients supports respiratory, gastrointestinal, and skin health in otherwise well-nourished, healthy children.
2.Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets.
Jacobi SK1, Yatsunenko T2, Li D3, Dasgupta S3, Yu RK3, Berg BM4, Chichlowski M5, Odle J6. J Nutr. 2016 Feb;146(2):200-8. doi: 10.3945/jn.115.220152. Epub 2015 Dec 23.
BACKGROUND: Sialyllactose is a key human milk oligosaccharide and consists of sialic acid (SA) bound to a lactose molecule. Breastfed infants have increased accumulation of ganglioside-bound SA compared with formula-fed infants.
3.Digestibility of new dietary fibre materials, resistant glucan and hydrogenated resistant glucan in rats and humans, and the physical effects in rats.
Oku T1, Tanabe K2, Morita S2, Hamaguchi N3, Shimura F1, Nakamura S1. Br J Nutr. 2015 Nov 28;114(10):1550-9. doi: 10.1017/S0007114515003311. Epub 2015 Oct 16.
Resistant glucan (RG) and hydrogenated resistant glucan (HRG) are newly developed non-digestible carbohydrate materials that decrease lifestyle-related diseases. The bioavailability of RG and HRG was investigated by in vitro experiments using human and rat small intestinal enzymes and by in vivo experiments using rats in the present study. Oligosaccharides, which are minor components of RG and HRG, were hydrolysed slightly by small intestinal enzymes of humans and rats, and the hydrolysing activity was slightly higher in rats than in humans. The amount of glucose released from HRG was greater than that from RG. However, the high-molecular-weight carbohydrates of the main components were hardly hydrolysed. Furthermore, neither RG nor HRG inhibited disaccharidase activity. When rats were raised on a diet containing 5 % of RG, HRG, resistant maltodextrin or fructo-oligosaccharide (FOS) for 4 weeks, all rats developed loose stools and did not recover during the experiment, except for the FOS group.
4.The effect of polydextrose and probiotic lactobacilli in a Clostridium difficile-infected human colonic model.
Forssten SD1, Röytiö H2, Hibberd AA3, Ouwehand AC4. Microb Ecol Health Dis. 2015 Oct 13;26:27988. doi: 10.3402/mehd.v26.27988. eCollection 2015.
BACKGROUND: Clostridium difficile is a natural resident of the intestinal microbiota; however, it becomes harmful when the normal intestinal microbiota is disrupted, and overgrowth and toxin production occurs. The toxins can cause bloating and diarrhoea, which may cause severe disease and have the potential to cause outbreaks in hospitals and other healthcare settings. Normally, antibiotic agents are used for treatment, although for some of the patients, these treatments provide only a temporary relief with a recurrence of C. difficile-associated diarrhoea.
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