Pogostone - CAS 23800-56-8
Catalog number: 23800-56-8
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Pogostone, that is isolated from the herbs of Pogostemon cablin (Blanco) Benth, possesses potent anti-bacterial and anti-fungal activities and has been used for the quality control of essential oil of Pogostemon cablin. It could inhibit both gram negative bacteria (0.098-1 600 µg/ml) and gram positive bacteria (0.098-800 µg/ml). Besides, Pogostone could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH. Pogostone exhibited an immunosuppressive property by directly blocking T cell proliferation as well as altering inflammatory cytokine profile.
DHELWANGIN; 4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one
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1.185±0.06 g/cm3
1.Evaluation of Contact Toxicity and Repellency of the Essential Oil of Pogostemon cablin Leaves and Its Constituents Against Blattella germanica (Blattodae: Blattelidae).
Liu XC;Liu Q;Chen H;Liu QZ;Jiang SY;Liu ZL J Med Entomol. 2015 Jan;52(1):86-92. doi: 10.1093/jme/tju003.
The aim of this research was to evaluate contact toxicity and repellency of the essential oil of Pogostemon cablin (Blanco) Bentham leaves against German cockroaches (Blattella germanica) (L.) and to isolate any active constituents. Essential oil of P. cablin leaves was obtained by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Twenty-three components were identified in the essential oil, and the main constituents were patchoulol (41.31%), pogostone (18.06%), α-bulnesene (6.56%), caryophyllene (5.96%), and seychellene (4.32%). Bioactivity-directed chromatographic separation of the essential oil led to the isolation of pogostone, patchoulol, and caryophyllene as active compounds. The essential oil of P. cablin leaves exhibited acute toxicity against male B. germanica adults with an LC50 value of 23.45 μg per adult. The constituent compound, pogostone (LC50 = 8.51 μg per adult) showed stronger acute toxicity than patchoulol (LC50 = 207.62 μg per adult) and caryophyllene (LC50 = 339.90 μg per adult) against the male German cockroaches. The essential oil of P. cablin leaves and the three isolated constituents exhibited strong repellent activity against German cockroaches at a concentration of 5 ppm.
2.Composition of the essential oil of Pogostemon travancoricus var. travancoricus.
Murugan R;Mallavarapu GR Nat Prod Commun. 2012 Jan;7(1):87-8.
The essential oil of Pogostemon travancoricus Bedd. var. travancoricus collected from the Agasthyamalai region of Tamil Nadu, India was analyzed by GC and GC-MS. The major components of the oil were bicyclogermacrene (16.0%), cis-calamenene (6.3%), germacrene B (11.1%), spathulenol (7.6%), viridiflorol (5.8%), alpha-cadinol (4.2%) and pogostone (9.9%).
3.Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.
Chen H;Liao H;Liu Y;Zheng Y;Wu X;Su Z;Zhang X;Lai Z;Lai X;Lin ZX;Su Z Fitoterapia. 2015 Jan;100:110-7. doi: 10.1016/j.fitote.2014.11.017. Epub 2014 Dec 3.
We examined the protective effect of pogostone (PO), a chemical constituent isolated from Pogostemonis Herba, on the ethanol-induced gastric ulcer in rats. Administration of PO at doses of 10, 20 and 40 mg/kg body weight prior to ethanol ingestion effectively protected the stomach from ulceration. The gastric lesions were significantly ameliorated by all doses of PO as compared to the vehicle group. Pre-treatment with PO prevented the oxidative damage and the decrease of prostaglandin E2 (PGE2) content. In addition, PO pretreatment markedly increased the mucosa levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), and decreased gastric malonaldehyde (MDA), relative to the vehicle group. In the mechanistic study, significant elevation of non-protein-sulfhydryl (NP-SH) was observed in the gastric mucosa pretreated by PO. Analysis of serum cytokines indicated that PO pretreatment obviously elevated the decrease of interleukin-10 (IL-10) level, while markedly mitigated the increment of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) secretions in ethanol-induced rats. Taken together, these results strongly indicate that PO could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH.
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