Plerixafor - CAS 110078-46-1
Catalog number: B0084-054319
Category: Inhibitor
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Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
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Catalog Number Size Price Stock Quantity
B0084-054319 25 mg $198 In stock
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Plerixafor; SDZ SID 791; Mozobil; JKL 169; JM 3100; JKL169; JM3100; JKL-169; JM-3100
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1. In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs
Huai-long Xu, Zi-jie Wang, Jin-ku Bao*. Mol. BioSyst., 2014, 10, 1524—1537
In order to compare the flexibility of each residue in single ABL1–inhibitor complexes, the RMSF was calculated (Fig. 7). In general, wild-type ABL1 bound with different drugs have similar RMSF profiles and it is the same for T315I ABL1. Moreover, considering the ATP binding site (residues 248–260 and 315–322) and the A-loop motif (residues 381–405), nilotinib and imatinib exhibited lower flexibility while chlorhexidine exhibited the highest flexibility in the T315I complex, indicating that bound with nilotinib and imatinib, wild-type ABL1 could maintain the ATP binding site and A-loop motif, leading to its inhibited ability. Sorafenib possessed similar flexibility to nilotinib and imatinib. However, in the T315I ABL1 complex, nicergoline and plerixafor exhibited lower flexibility than ponatinib, indicating that nicergoline and plerixafor could form a stronger interaction with T315I ABL1.
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