Plerixafor - CAS 110078-46-1
Catalog number: B0084-054319
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H54N8
Molecular Weight:
502.78
COA:
Inquire
Targets:
CXCR
Description:
Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-054319 25 mg $198 In stock
Bulk Inquiry
Purity:
>98%
Synonyms:
Plerixafor; SDZ SID 791; Mozobil; JKL 169; JM 3100; JKL169; JM3100; JKL-169; JM-3100
MSDS:
Inquire
InChIKey:
YIQPUIGJQJDJOS-UHFFFAOYSA-N
InChI:
InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2
Canonical SMILES:
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
1. In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs
Huai-long Xu, Zi-jie Wang, Jin-ku Bao*. Mol. BioSyst., 2014, 10, 1524—1537
In order to compare the flexibility of each residue in single ABL1–inhibitor complexes, the RMSF was calculated (Fig. 7). In general, wild-type ABL1 bound with different drugs have similar RMSF profiles and it is the same for T315I ABL1. Moreover, considering the ATP binding site (residues 248–260 and 315–322) and the A-loop motif (residues 381–405), nilotinib and imatinib exhibited lower flexibility while chlorhexidine exhibited the highest flexibility in the T315I complex, indicating that bound with nilotinib and imatinib, wild-type ABL1 could maintain the ATP binding site and A-loop motif, leading to its inhibited ability. Sorafenib possessed similar flexibility to nilotinib and imatinib. However, in the T315I ABL1 complex, nicergoline and plerixafor exhibited lower flexibility than ponatinib, indicating that nicergoline and plerixafor could form a stronger interaction with T315I ABL1.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CXCR Products


CAS 110078-46-1 Plerixafor

Plerixafor
(CAS: 110078-46-1)

Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

CAS 473727-83-2 SCH 527123

SCH 527123
(CAS: 473727-83-2)

A potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.

KRH1636
(CAS: 568526-77-2)

KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. ...

CAS 473719-41-4 (±)-AMG 487

(±)-AMG 487
(CAS: 473719-41-4)

CXCR3 antagonist; Inhibits cell migration and metastasis

CAS 113558-15-9 Baohuoside I

Baohuoside I
(CAS: 113558-15-9)

A regulator of CXCR4 expression

FC 131
(CAS: 606968-52-9)

CXCR4 antagonist

CAS 266359-93-7 Reparixin L-lysine salt

Reparixin L-lysine salt
(CAS: 266359-93-7)

The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 u...

CAS 1204707-73-2 SRT3190

SRT3190
(CAS: 1204707-73-2)

A CXCR2 ligand

Chemical Structure

CAS 110078-46-1 Plerixafor

Quick Inquiry

Verification code

Featured Items