Plecanatide - CAS 467426-54-6
Catalog number: B0084-482218
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C65H104N18O26S4
Molecular Weight:
1681.89
COA:
Inquire
Targets:
Guanylate Cyclase
Description:
Plecanatide, also called Trulance, a synthetic analogue of uroguanylin, is a guanylate cyclase-C (GCC) agonist being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). In January 2017, an oral formulation of plecanatide received its first global approval in the USA for the treatment of adult patients with CIC. Besides, Plecanatide is undergoing phase III investigation in IBS-C. It had also undergone preclinical investigations in inflammatory bowel disease (IBD) and ulcerative colitis; however, development in these indications has been discontinued.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-482218 5 mg $295 In stock
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Brife Description:
A guanylate cyclase-C agonist received global approval in the USA to treat adultpatients with CIC
Sequence:
H-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH
Synonyms:
L-​Leucine, L-​asparaginyl-​L-​α-​aspartyl-​L-​α-​glutamyl-​L-​cysteinyl-​L-​α-​glutamyl-​L-​leucyl-​L-​cysteinyl-​L-​valyl-​L-​asparaginyl-​L-​valyl-​L-​alanyl-​L-​cysteinyl-​L-​threonylglycyl-​L-​cysteinyl-​, cyclic (4→12)​,​(7→15)​-​bis(disulfide); 105: PN: WO2012037380 SEQID: 105 claimed protein; 1: PN: US20100152118 SEQID: 1 claimed protein; 1: PN: WO2008151257 SEQID: 1 claimed protein; 1: PN: WO2010065751 SEQID: 1 claimed protein; 1: PN: WO2011069038 SEQID: 1 claimed sequence; 1: PN: WO2012037380 SEQID: 1 claimed protein; 1: PN: WO2014131024 SEQID: 1 claimed protein; 1: PN: WO2015054500 SEQID: 1 claimed protein; 1: PN: WO2015054649 SEQID: 1 claimed protein; 20: PN: WO02078683 SEQID: 20 claimed protein; 78: PN: WO2010065751 SEQID: 105 claimed protein; 7: PN: WO2015054500 SEQID: 105 claimed protein; 8: PN: WO2015054500 SEQID: 106 claimed protein; 9: PN: WO2015054500 SEQID: 107 claimed protein; SP 304; Trulance
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Boiling Point:
2120.0±65.0 °C | Condition: Press: 760 Torr
Density:
1.47±0.1 g/cm3
InChIKey:
NSPHQWLKCGGCQR-DLJDZFDSSA-N
InChI:
1S/C65H104N18O26S4/c1-25(2)15-34-55(98)80-41-24-113-110-21-38(58(101)77-37(65(108)109)16-26(3)4)71-44(87)20-69-62(105)50(30(10)84)83-61(104)40(78-51(94)29(9)70-63(106)48(27(5)6)81-57(100)35(18-43(68)86)76-64(107)49(28(7)8)82-60(41)103)23-112-111-22-39(59(102)73-32(53(96)75-34)11-13-45(88)89)79-54(97)33(12-14-46(90)91)72-56(99)36(19-47(92)93)74-52(95)31(66)17-42(67)85/h25-41,48-50,84H,11-24,66H2,1-10H3,(H2,67,85)(H2,68,86)(H,69,105)(H,70,106)(H,71,87)(H,72,99)(H,73,102)(H,74,95)(H,75,96)(H,76,107)(H,77,101)(H,78,94)(H,79,97)(H,80,98)(H,81,100)(H,82,103)(H,83,104)(H,88,89)(H,90,91)(H,92,93)(H,108,109)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,48-,49-,50-/m0/s1
Canonical SMILES:
CC(C)C[C@H](NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC2=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(=O)N)C(=O)O
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