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  3. Drug Discovery
  4. Inhibitor
  5. Cardiovascular and blood system
  6. HMG-CoA Reductase (HMGCR)
  7. Pitavastatin calcium
Pitavastatin calcium
Pitavastatin calcium Chemical Structure

Pitavastatin calcium

Catalog NO.: B0084-059146 CAS NO.: 147526-32-7 Brand: BOC Sciences

Category
Inhibitor
Tag/Targets
HMG-CoA Reductase (HMGCR)
Molecular Formula
C50H46CaF2N2O8
Molecular Weight
880.98
Size Price Stock Quantity
1 g $199 In stock

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WARNING: Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Pitavastatin calcium is a novel member of the medication class of statins.

Boiling Point
692.0 °C at 760 mmHg
Melting Point
> 138 °C (dec.)
InChI Key
RHGYHLPFVJEAOC-FFNUKLMVSA-L
InChI
InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1
SMILES
C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
COA
HNMR
HPLC
NCT NumberTitleCondition Or DiseasePhaseStart DateSponsorStatus
NCT02056847to Evaluate the Safety and Efficacy of Pitavastatin in Patients With IFG and HyperlipidemiaHbA1c Level Associated With Lipid CompositionsPhase 4September 2013JW PharmaceuticalCompleted
NCT02670434Safety and Efficacy Comparison Study of NK-104-CR (Controled Release) in Patients With Primary Hyperlipidemia or Mixed DyslipidemiaHyperlipidemiaPhase 3January 2016Kowa Research Institute, Inc.Terminated
NCT03532620China Protection Trial of Glucose Metabolism by Pitavastatin in Patients With Prediabetes and HypertensionPrediabetic StatePhase 4May 2018Jun TaoRecruiting
Write a review Ask a question

Dear team, how does Pitavastatin calcium induce apoptosis in oral squamous cell carcinoma?

I'd like to. Pitavastatin calcium induces apoptosis in oral squamous cell carcinoma through activation of FOXO3a.

9/9/2017

Could you please give me some information on how Pitavastatin calcium attenuates AGEs-induced mitophagy?

Pitavastatin calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes.

30/10/2017

Dear Sir, please give information about how Pitavastatin calcium stimulates retinal angiogenesis.

Yeah! Pitavastatin calcium stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion.

25/12/2020

lead to significant tumour regression

Pitavastatin calcium can lead to significant tumour regression.

6/5/2016

inhibit the growth of a panel of ovarian cancer cells

The inhibitive effect was very good and specific. Pitavastatin calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50 = 0.4-5 μM) or as spheroids (IC50=0.6-4 μM).

7/9/2016

cause PARP cleavage

The effect of Pivastatin on PARP division in Ovcar-8 cells is very good, and we have successfully completed the study.

24/12/2016

1. Effect of a single-dose rifampin on the pharmacokinetics of pitavastatin in healthy volunteers
Yao Chen & Wei Zhang & Wei-hua Huang & Zhi-rong Tan. Eur J Clin Pharmacol (2013) 69:1933–1938
The study had a randomized crossover design with two periods that were separated by a 2-week washout period. During the study periods, the volunteers received administrations of either 4 mg pitavastatin calcium, or 4 mg pitavastatin calcium in combination with 600 mg rifampin capsule swallowed by 150 ml water, then a series venous blood samples of 5 ml were collected into EDTA-containing tubes at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12, 24 and 48 h. After the washout period, the experiment was carried out by crossover. The plasma samples were separated by centrifugation and immediately stored in polypropylene tubes at −40 °C until analysis.
2. Determination of Pitavastatin in Human Plasma by LC–MS–MS
Jianzhong Shen-Tu, Xiao Xu, Jian Liu*. Chromatographia 2009, 69, May (No. 9/10)
We have developed a simple and rapid LC–MS–MS method using acetonitrile as protein precipitation solvent to determine pitavastatin in human plasma. Convenient sample preparation and high sensitivity are the main advantages of the technique. The method has been validated and applied successfully to a clinical study after single oral doses of 1, 2 and 4 mg pitavastatin calcium tablets.
Preparing Stock Solutions
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM1.1351 mL5.6755 mL11.3510 mL
5 mM0.2270 mL1.1351 mL2.2702 mL
10 mM0.1135 mL0.5675 mL1.1351 mL
50 mM0.0227 mL0.1135 mL0.2270 mL
About Us

BOC Sciences is a trusted global supplier of research chemicals, biochemicals, and pharmaceutical ingredients, serving the life sciences, biotech, and pharmaceutical industries. Headquartered in New York, we offer a comprehensive product portfolio that includes inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP products, impurities and metabolites, APIs, natural compounds, ADC-related chemicals, and stem cell molecules.

We specialize in the synthesis, biosynthesis, purification, and characterization of small molecules. With years of industry experience, our scientific and technical teams support projects ranging from early discovery to process development and regulatory submission.

BOC Sciences operates GMP-compliant and ISO-certified production facilities, ensuring consistent quality and regulatory alignment. Our products and services are trusted by clients in over 60+ countries, including top pharmaceutical companies, academic institutions, and research organizations.

We are committed to providing high-quality chemicals, responsive technical support, and flexible custom solutions to accelerate innovation in drug discovery and development.

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