|Description||Pirarubicin Hydrochloride is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. It intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.|
Bisantrene Dihydrochloride is the hydrochloride salt of Bisantrene. Bisantrene, also referred to CL-216942, Cyabin or NSC-337766, an anthracene bishydrazone der...
Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (h...
Grepafloxacin is a quinoline antibacterial agent used to treat various bacterial infections.
CS1 is a Topo IIα inhibitor with broad-spectrum in vitro antitumor activity. CS1 acts as a Topo II poison to stabilize Topo II/DNA complex causing DNA damage, c...
Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
Elinafide, an isoquinoline derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in anticancer studies.
NSC 660028, an arylamino etoposide analogue, has been found to be a DNA topoisomerase II inhibitor that was once studied due to its potential anticancer activit...
Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and ex...