Pipobroman - CAS 54-91-1
Catalog number: 54-91-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H16Br2N2O2
Molecular Weight:
356.05
COA:
Inquire
Targets:
Others
Description:
Pipobroman (trade names Vercite, Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. It is marketed by Abbott Laboratories. Pipobroman (PB) has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET).
Purity:
>98%
Synonyms:
3-bromo-1-[4-(3-bromopropanoyl) piperazin-1-yl]-propan-1-one
MSDS:
Inquire
InChIKey:
NJBFOOCLYDNZJN-UHFFFAOYSA-N
InChI:
InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
Canonical SMILES:
C1CN(CCN1C(=O)CCBr)C(=O)CCBr
1.Treatment of polycythemia vera with hydroxyurea and pipobroman: final results of a randomized trial initiated in 1980.
Kiladjian JJ1, Chevret S, Dosquet C, Chomienne C, Rain JD. J Clin Oncol. 2011 Oct 10;29(29):3907-13. doi: 10.1200/JCO.2011.36.0792. Epub 2011 Sep 12.
PURPOSE: The overall impact of hydroxyurea (HU) or pipobroman treatments on the long-term outcome of patients with polycythemia vera (PV) has not been assessed in randomized studies. We report final analyses from the French Polycythemia Study Group (FPSG) study, which randomly assigned HU versus pipobroman as first-line therapy in 285 patients younger than age 65 years.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


Cp-76593
(CAS: 115898-30-1)

This active molecular is a bio-active chemical and detailed information has not been published yet.

CAS 1007647-73-5 A01

A01
(CAS: 1007647-73-5)

A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Stu...

CAS 83657-24-3 Diniconazole

Diniconazole
(CAS: 83657-24-3)

Diniconazol is a chemical compound belongs to chlorine group of conazole. It is used as fungicide. It inhibited lanosterol 14 alpha-demethylation catalyzed by a...

CAS 1160928-63-1 RETF-4NA

RETF-4NA
(CAS: 1160928-63-1)

RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G.

KLS-13019
(CAS: 1801243-39-9)

KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol.

CAS 83480-29-9 Voglibose

Voglibose
(CAS: 83480-29-9)

Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various d...

Cgp-17520
(CAS: 101706-66-5)

Cgp-17520 is a new bio-active cephalosporin anti-biotic chemical comound synthesized by Ciba Geigy Ltd.

CAS 55395-07-8 IKarisoside A

IKarisoside A
(CAS: 55395-07-8)

IKarisoside A is a natural compound isolated from Epimedium koreanum, which has anti-inflammatory properties.

CAS 3644-61-9 Tolperisone Hydrochloride

Tolperisone Hydrochloride
(CAS: 3644-61-9)

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.

Gemilukast disodium salt
(CAS: 1232861-64-1)

Gemilukast, also known as ONO-6950, is an orally active dual CysLT1 and CysLT2 antagonist. Gemilukast exhibited antagonist activities with IC50 values of 1.7 an...

CAS 61276-17-3 Verbascoside

Verbascoside
(CAS: 61276-17-3)

Verbascoside is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity, which is a protein kinase C inhibitor.

CAS 1469284-79-4 PF 06424439

PF 06424439
(CAS: 1469284-79-4)

PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1...

CAS 229971-81-7 Exherin

Exherin
(CAS: 229971-81-7)

Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 select...

CAS 60-56-0 Methimazole

Methimazole
(CAS: 60-56-0)

Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug,and part of the thioamide group. Like its counterpart propylthiouracil, a major...

CAS 1982372-88-2 A 196

A 196
(CAS: 1982372-88-2)

A 196 is a potent and selective inhibitor of SUV420H1/H2 (IC50 = 25 and 144 nM, respectively) with 100-fold selectivity over other histone methyltransferases an...

CAS 3562-99-0 Menbutone

Menbutone
(CAS: 3562-99-0)

An oxobutyric acid derivative which is used for stimulating gastro-intestinal function.

CAS 80321-63-7 Gynostemma Extract

Gynostemma Extract
(CAS: 80321-63-7)

Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.

CAS 100-55-0 3-(Hydroxymethyl)pyridine

3-(Hydroxymethyl)pyridine
(CAS: 100-55-0)

3-Pyridinemethanol, an aromatic alcohol compound, is a widely used in the synthesis of some inhibitors like Chk1 and histone deacetylase inhibitors.

CB 3731
(CAS: 80015-07-2)

CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase.

CAS 123-99-9 1,7-Heptanedicarboxylic Acid

1,7-Heptanedicarboxylic Acid
(CAS: 123-99-9)

Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.

Chemical Structure

CAS 54-91-1 Pipobroman

Quick Inquiry

Verification code

Featured Items