Piperolactam C - CAS 116064-76-7
Catalog number: 116064-76-7
Not Intended for Therapeutic Use. For research use only.
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Piperolactam C is an alkaloid compound found in the roots of Piper longum L. The compound can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
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Yellow powder
2-O-Methylaristolactam FII;3-Methoxyaristolactam BII;O-Methylpiperolactam B;Piperolactam B methyl ether
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1.In Vitro susceptibilities of wild and drug resistant Leishmania donovani amastigotes to piperolactam A loaded hydroxypropyl-β-cyclodextrin nanoparticles.
Bhattacharya P1, Mondal S2, Basak S3, Das P4, Saha A5, Bera T6. Acta Trop. 2016 Jun;158:97-106. doi: 10.1016/j.actatropica.2016.02.017. Epub 2016 Mar 3.
Leishmaniasis is an epidemic in various countries, and the parasite Leishmania donovani is developing resistance against available drugs. In the present study the antileishmanial action of piperolactam A (PL), isolated after bioactivity guided fractionation from root extracts of Piper betle was accentuated in detail. Activity potentiation was achieved via cyclodextrin complexation. Crude hydro-ethanolic extract (PB) and three fractions obtained from PB and fabricated PL-hydroxypropyl-β-cyclodextrin (HPBCD) nanoparticles were evaluated for antileishmanial activity. Tests were performed against L. donovani wild-type, sodium stibogluconate, paromomycin and field isolated (GE1) resistant strains in axenic amastigote and amastigote in macrophage models. PL-HPBCD complex was characterized and FITC loaded HPBCD nanoparticles were assessed for macrophage internalization in confocal microscopic studies. Isolated and purified PL from most potent, alkaloid rich ethyl acetate fraction of PB showed high level of antileishmanial activities in wild-type (IC50=36μM), sodium stibogluconate resistant (IC50=103μM), paromomycin resistant (IC50=91μM) and field isolated resistant (IC50=72μM) strains together with cytotoxicity (CC50=900μM) in mouse peritoneal macrophage cells.
2.Aristolactams, 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil and other bioactive constituents of Toussaintia orientalis.
Odalo JO1, Joseph CC, Nkunya MH, Sattler I, Lange C, Friedrich G, Dahse HM, Möllman U. Nat Prod Commun. 2010 Feb;5(2):253-8.
The new aristolactam alkaloid toussalactam {2-hydroxy-1,6-dimethoxy-5H-dibenzo[cdf]indol-4-one} and the known ones, namely aristolactam AII, aristolactam BII, piperolactam C and aristolactam FII; 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, and three catechinoids were isolated from the cytotoxic Toussaintia orientalis Verdc stem and root bark extracts, and their structures established based on analysis of spectroscopic data. The aristolactams exhibited antimicrobial and antiinflammatory activity, aristolactam FII showing almost the same level of activity as the standard anti-inflammatory agent Indomethacin. The compounds also exhibited either mild or no antiproliferative and cytotoxic activities, except aristolactam FII that showed the same level of cytotoxicity as the standard drug Camptothecin. 1-(2-C-Methyl-beta-D-ribofuranosyl)-uracil, which is being reported for the first time as a natural product, was inactive in the antibacterial, antifungal, antiinflammatory, antiproliferative and cytotoxicity assays.
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CAS 116064-76-7 Piperolactam C

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