pikamilone sodium - CAS 62936-56-5
Catalog number: B0084-400026
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H11N2NaO3
Molecular Weight:
230.199
COA:
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Targets:
Others
Description:
Pikamilone sodium is a prodrug of GABA that is used in the treatment of benign prostatic hyperplasia and neurogenic bladder in spinal.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-400026 5 g $149 In stock
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Brife Description:
prodrug of GABA
Purity:
> 98%
Synonyms:
Pikamilone sodium salt; Picamilon; Pikamilon sodium; Nicotinoyl-GABA sodium salt
MSDS:
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Application:
the treatment of benign prostatic hyperplasia
InChIKey:
DGWZSECHAXUHPD-UHFFFAOYSA-M
InChI:
InChI=1S/C10H12N2O3.Na/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8;/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14);/q;+1/p-1
Canonical SMILES:
C1=CC(=CN=C1)C(=O)NCCCC(=O)[O-].[Na+]
1.[The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain].
Akopian VP;Balian LS;Avetisian NA Eksp Klin Farmakol. 2006 Mar-Apr;69(2):10-3.
The influence of a 15-day hypokinesia on the development of anxiety-depression state and quantitative changes in the central GABA-A macromolecular receptor complexes in the rat brain has been investigated under conditions of the despair (forced swim) test. Simultaneously, the effects of well-known nootropic drugs picamilon and piracetam on the dynamics of state parameters in the experimental animals have been evaluated. It was found that hypokinesia led to the development of anxiety and depression accompanied by reduction in the amount of active GABA-A receptors. The injections of piracetam and picamilon showed a tendency to restoration of the number of active GABA-A receptors and to normalization of the behavioral parameters.
2.[The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect].
Novikov VE;Kovaleva LA Eksp Klin Farmakol. 1998 Mar-Apr;61(2):65-8.
A craniocerebral trauma was modelled in experiments on one-month-old rats. Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg). It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma. Nooglutyl surpasses all the other drugs in its influence on the effectiveness of oxidative phosphorylation of mitochondria in immature rats in the posttraumatic period.
3.[Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze].
Voznesenskiĭ AG;Kovalev GV;Sazhin VA Farmakol Toksikol. 1989 Jul-Aug;52(4):14-7.
During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze.
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CAS 62936-56-5 pikamilone sodium

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