Phytol - CAS 150-86-7
Catalog number: B0005-332663
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Phytol isolated from the leaves of Black tea. It attenuates the inflammatory response by inhibiting neutrophil migration, which is partly caused by reduction in IL-1β and TNF-α levels and oxidative stress.
antimycobacterial; anti-tumor; anti-cancer ;anxiolytic activities.
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1.Pheophytinase Knockdown Impacts Carbon Metabolism and Nutraceutical Content Under Normal Growth Conditions in Tomato.
Lira BS;Rosado D;Almeida J;de Souza AP;Buckeridge MS;Purgatto E;Guyer L;Hörtensteiner S;Freschi L;Rossi M Plant Cell Physiol. 2016 Mar;57(3):642-53. doi: 10.1093/pcp/pcw021. Epub 2016 Feb 14.
Although chlorophyll (Chl) degradation is an essential biochemical pathway for plant physiology, our knowledge regarding this process still has unfilled gaps. Pheophytinase (PPH) was shown to be essential for Chl breakdown in dark-induced senescent leaves. However, the catalyzing enzymes involved in pigment turnover and fruit ripening-associated degreening are still controversial. Chl metabolism is closely linked to the biosynthesis of other isoprenoid-derived compounds, such as carotenoids and tocopherols, which are also components of the photosynthetic machinery. Chls, carotenoids and tocopherols share a common precursor, geranylgeranyl diphosphate, produced by the plastidial methylerythritol 4-phosphate (MEP) pathway. Additionally, the Chl degradation-derived phytol can be incorporated into tocopherol biosynthesis. In this context, tomato turns out to be an interesting model to address isoprenoid-metabolic cross-talk since fruit ripening combines degreening and an intensely active MEP leading to carotenoid accumulation. Here, we investigate the impact of PPH deficiency beyond senescence by the comprehensive phenotyping of SlPPH-knockdown tomato plants. In leaves, photosynthetic parameters indicate altered energy usage of excited Chl.
2.Biosynthesis of the hemi- and monoterpene moieties of isoprenyl phenyl ethers from the liverwort Trichocolea tomentella.
Barlow AJ;Becker H;Adam KP Phytochemistry. 2001 May;57(1):7-14.
The incorporation of 13C labelled glucose into trichocolein, deoxytomentellin, trans-phytol and stigmasterol has been studied in axenic cultures of the liverwort Trichocolea tomentella. Quantitative 13C NMR spectroscopic analysis of the resulting labelling patterns showed that the isoprene units of the hemi- and monoterpenoid moieties and the diterpene phytol are derived from the methylerythritol phosphate pathway, whereas the isoprene units of stigmasterol are built up via the mevalonic acid pathway. These results indicate the involvement of both IPP biosynthetic pathways in different cellular compartments. A new, hydroperoxy geranyl phenyl ether derivative is also described.
3.Inhibition of Ca2+-induced cytosolic enzyme efflux from skeletal muscle by vitamin E and related compounds.
Phoenix J;Edwards RH;Jackson MJ Biochem J. 1989 Jan 1;257(1):207-13.
1. Efflux of an intracellular enzyme (creatine kinase) from normal rat skeletal muscles was induced by treatment with the Ca2+ ionophore A23187. Addition of alpha-tocopherol (230 microM) to the incubation medium was found to significantly diminish this efflux, and this effect was mimicked by alpha-tocopherol acetate, phytol and isophytol, but not by Trolox C (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid). 2. Analysis of muscle cation content has shown that these protective effects of alpha-tocopherol etc. are not due to an inhibition of the Ca2+ accumulating effects of the ionophore. 3. Non-enzymic lipid peroxidation of skeletal-muscle homogenates was found to be inhibited by alpha-tocopherol and Trolox C, partially inhibited by phytol and isophytol, but unaffected by alpha-tocopherol acetate. 4. The activity of lipoxygenase enzymes was partially inhibited by alpha-tocopherol, phytol and isophytol, but not by alpha-tocopherol acetate or Trolox C. 5. Prostaglandin E2 efflux from isolated skeletal muscles was stimulated by treatment with the Ca2+ ionophore, but this was unaffected by alpha-tocopherol treatment.
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CAS 150-86-7 Phytol

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