Pheniramine Maleate - CAS 132-20-7
Catalog number: 132-20-7
Category: Inhibitor
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Molecular Formula:
C16H20N2.C4H4O4
Molecular Weight:
356.42
COA:
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Targets:
Histamine Receptor
Description:
Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.
Purity:
>98%
Synonyms:
N/A
MSDS:
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InChIKey:
SSOXZAQUVINQSA-BTJKTKAUSA-N
InChI:
InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Canonical SMILES:
CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
1. Influence of Pheniramine and Chlorpheniramine on Apomorphine Induced Compulsive Gnawing in Mice
N. K. DADKAR, A. N. DOHADWALLA, and B. K. BHATTACHARYA. Psychopharmacology 48, 7-10 (1976)
The following ubstances were used: Apomorphine hydrochloride, pheniramine maleate, chlorpheniramine maleate, mepyramine maleate, physostigmine salicylate,L-Dopa, tetrabenazine methoxy sulphonate, α-methyl-para-tyrosine methylester hydrochloride (e-MPT), bis-(4-methyl-l-homopiperazinylthiocarbonyl)-disulphide (FLA-63), haloperidol, phenoxybenzamine hydrochloride, methysergide bimaleate, p-chloro-phenylalanine methylester hydrochloride (p-CPA). All drug solutions were prepared daily at concentrations which required volume doses of 10 ml/kg. All substances except FLA-63, haloperidol, L-Dopa were dissolved in physiological saline. Haloperidol was dissolved in 0.1 M tartaric acid and diluted with water. FLA-63 and L-Dopa were dissolved in a few drops of 2N HCI, the final volume was made up with saline and the solution was neutralised with 2N NaOH. The substances were always administered intraperitoneally (i.p.) and given in doses and time intervals as shown in Table 1.
2. First Derivative Spectrophotometric and Gas-Liquid Chromatographic Determination of Caffeine in Foods and Pharmaceuticals III. Simultaneous assay of caffeine and some antihistaminics
Ezzat M. AbdeI-Moety, Mohamed F. EI-Tarras, Badr-Eldin A. EI-Zeany and Khadiga O. Kelani. Arch. Pharm. Res. 13(3), 215-220
UV-scanning of ethanolic solutions of mixtures containing caffeine and chlorpheniramine maleate show band overlap of the maxima of caffeine at 273 nm and or chlorpheniramine maleate at 262 nm in the zero-order (Do), Fig. la. On the other hand, the first-derivative (DI) scanning of the same binary mixtures of the individual drug substances exhibits that caffeine has a typical trough at about 288 nm while chlorpheniramine maleate shows zero or negligible absorption reading at that wavelength. Similarly, when chlorpheniramine maleate reads maximally at about 273 nm, caffeine has no measurable absorbance, Fig. lb. On the bases of such observations, it would be possible then to adopt derivative spectrophotometry for the determination of both drug substances simulataneously in their mixtures. Linear relationship between the amplitude height in the D1-spectra [d'A/d/, i.e. (d'A)] and the concentration of caffeine and chlor- pheniramine maleate have been found in the ranges of 8-40μg ml-1(ppm), respectively. Statistical evaluation of the obtained results demonstrates low figures of relative standard deviation (SDr) for caffeine and chlorpheniramine maleate (0.006 and 0.007, respectively) on applying the D1-spectrophotometric technique.
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