PF 514273 - CAS 851728-60-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Cannabinoid Receptor
PF 514273 is a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively.
≥98% by HPLC
PF 514273; PF514273; PF-514273; 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
Store in a cool and dry place (or refer to the Certificate of Analysis).
Canonical SMILES:
1.Effects of the novel cannabinoid CB1 receptor antagonist PF 514273 on the acquisition and expression of ethanol conditioned place preference.
Pina MM;Cunningham CL Alcohol. 2014 Aug;48(5):427-31. doi: 10.1016/j.alcohol.2014.01.013. Epub 2014 May 21.
The centrally expressed cannabinoid receptor (CB1) has been considered a potential therapeutic target in treating alcoholism. Though CB1 receptors have been shown to modulate primary and conditioned ethanol reward, much of this research employed animal models that require ethanol ingestion or oral routes of administration. This is problematic considering CB1 antagonist drugs have high anorectic liability and have been used clinically in the treatment of obesity. Therefore, the present study examined CB1 antagonism in DBA/2J mice using an unbiased ethanol-induced conditioned place preference (CPP) procedure, a paradigm that does not require ethanol ingestion. To evaluate the role of CB1 receptors in primary ethanol reward, the highly potent and selective novel CB1 antagonist 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF 514273) was administered 30 min before place preference conditioning with a fixed dose of ethanol (acquisition). To evaluate the role of CB1 receptors in ethanol-conditioned reward, PF 514273 was administered 30 min before place preference testing (expression). Although PF 514273 reduced ethanol-stimulated and basal locomotor activity, it did not perturb the acquisition or expression of ethanol-induced CPP.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cannabinoid Receptor Products

CAS 23470-00-0 2-Palmitoylglycerol

(CAS: 23470-00-0)

2-Palmitoylglycerol is an endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol. It is an endogenous agonist of the CB1 and CB2 c...

CAS 536697-79-7 O-1918

(CAS: 536697-79-7)

O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also a...

CAS 544-31-0 Palmitoylethanolamide

(CAS: 544-31-0)

Palmitoylethanolamide is an endogenous cannabinoid found in brain, liver, and other mammalian tissues. It is a weak ligand of the cannabinoid 1 (CB1) and cannab...

CAS 212188-60-8 BAY 38-7271

BAY 38-7271
(CAS: 212188-60-8)

BAY 38-7271, also called as KN 38-7271, is a cannabinoid receptor agonist with analgesic and neuroprotective effects. The doses of BAY 38-7271 in animals needed...

LEI 101 hydrochloride

LEI 101 hydrochloride is a CB2 partial agonist with pEC50 value of 8.0. It shows antinociceptive activity in a rat neuropathic pain model. LEI 101 hydrochloride...

CAS 851320-29-1 O-2050

(CAS: 851320-29-1)

O-2050 is a high affinity neutral cannabinoid 1-receptor silent antagonist. It is used for the mechanistic effects and analysis of cannabinoids in the body. It ...

CAS 131543-23-2 WIN 55212-2 mesylate

WIN 55212-2 mesylate
(CAS: 131543-23-2)

The mesylate salt form of WIN 55212-2, an aminoalkylindole derivative, is a CB receptor agonist and could be effective against some inflammatory reponse. IC50: ...

CAS 164178-33-0 Iodopravadoline (AM630)

Iodopravadoline (AM630)
(CAS: 164178-33-0)

Iodopravadoline, also known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor. Iodopravadoline has been found to attenuate the ability of a ...

Chemical Structure

CAS 851728-60-4 PF 514273

Quick Inquiry

Verification code

Featured Items