PF-3274167 - CAS 900510-03-4
Catalog number: 900510-03-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H19ClFN5O3
Molecular Weight:
419.84
COA:
Inquire
Targets:
Others
Description:
PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
Purity:
98%
Appearance:
Solid powder
Synonyms:
PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167.
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
Canonical SMILES:
COC1=NC=C(N2C(N3CC(OC4=CC=C(F)C=C4Cl)C3)=NN=C2COC)C=C1
1.[
Vidal B;Karpenko IA;Liger F;Fieux S;Bouillot C;Billard T;Hibert M;Zimmer L Nucl Med Biol. 2017 Dec;55:1-6. doi: 10.1016/j.nucmedbio.2017.07.008. Epub 2017 Aug 2.
INTRODUCTION: ;Oxytocin plays a major role in the regulation of social interactions in mammals by interacting with the oxytocin receptor (OTR) expressed in the brain. Furthermore, the oxytocin system appears as a possible therapeutic target in autism spectrum disorders and other psychiatric troubles, justifying current pharmacological researches. Since no specific PET radioligand is currently available to image OTR in the brain, the aim of this study was to radiolabel the specific OTR antagonist PF-3274167 and to evaluate [;11;C]PF-3274167 as a potential PET tracer for OTR in rat brains.;METHODS: ;[;11;C]PF-3274167 was prepared via the O-methylation of its desmethyl precursor with [;11;C]methyl iodide. The lipophilicity of the radioactive compound was evaluated by measuring the n-octanol-buffer partition coefficient (logD). Autoradiography experiments were performed on rat brain tissue to evaluate the in vitro distribution of the [;11;C]PF-3274167. MicroPET experiments were conducted with and without pre-injection of ciclosporin in order to evaluate the influence of the P-glycoprotein (P-gp) on the brain uptake.;RESULTS: ;[;11;C]PF-3274167 was synthesized with high radiochemical and chemical purities (>95%) and good specific activity.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


FR-193262
(CAS: 187992-22-9)

FR-193262 is a designed prostacyclin mimetic without PG skeleton which exhibits potent PGI2 agonistic activity with good selectivity for IP receptor and bioavai...

CAS 7432-28-2 Schisandrin

Schisandrin
(CAS: 7432-28-2)

Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.

CAS 110623-73-9 Epmedin B

Epmedin B
(CAS: 110623-73-9)

Epimedin B, a flavonoids natural product extracted from Herbal Epimedium, has been studied to have potential antiosteoporotic effect.

CAS 1217022-63-3 PTC-209 hydrobromide

PTC-209 hydrobromide
(CAS: 1217022-63-3)

Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-...

CAS 163133-43-5 4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE

4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NA
(CAS: 163133-43-5)

Naproxcinod, a nitro compound, has been found to be a nitric oxide donor as well as a cyclooxygenase inhibitor that was once studied aginast duchenne muscular d...

AMG-747
(CAS: 1000690-85-6)

AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycine...

CAS 1218942-37-0 GKT137831

GKT137831
(CAS: 1218942-37-0)

GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.

CAS 88903-69-9 (-)-Xestospongin C

(-)-Xestospongin C
(CAS: 88903-69-9)

(-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-i...

Chemical Structure

CAS 900510-03-4 PF-3274167

Quick Inquiry

Verification code

Featured Items