|Description||PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model.|
|Purity||≥98% by HPLC|
|Related CAS||1469284-78-3 (free base); 1469284-80-7 (HCl)|
|Synonyms||[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate; PF-06424439; PF06424439; PF 06424439; PF-6424439; PF-6424439; PF 6424439|
|Solubility||Water to 100 mM; DMSO to 100 mM; ethanol to 100 mM|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
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