PF 04449613 - CAS 1236858-52-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H25N5O3
Molecular Weight:
395.45
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM), and also shows a high affinity for cGMP (Km ~170 nM). Some studies suggest that elevating the level of cGMP with the PDE9 inhibitor PF-04449613 increases synaptic calcium activity and learning-dependent synaptic plasticity.
Purity:
≥98% by HPLC
Synonyms:
(R)-6-(1-(3-Phenoxyazetidin-1-yl)ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one, 6-[(1R)-1-(3-Phenoxyazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; PF 4449613; PF 9613; PF4449613; PF9613; PF-4449613; PF-9613
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
InChIKey:
WEDCMPMDOVEMSV-CQSZACIVSA-N
InChI:
InChI=1S/C21H25N5O3/c1-14(25-12-17(13-25)29-16-5-3-2-4-6-16)19-23-20-18(21(27)24-19)11-22-26(20)15-7-9-28-10-8-15/h2-6,11,14-15,17,22H,7-10,12-13H2,1H3/t14-/m1/s1
Canonical SMILES:
CC(C1=NC(=O)C2=CNN(C2=N1)C3CCOCC3)N4CC(C4)OC5=CC=CC=C5
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Chemical Structure

CAS 1236858-52-8 PF 04449613

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