PF-04217903 methanesulfonate - CAS 956906-93-7
Catalog number: 956906-93-7
Category: Inhibitor
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Molecular Formula:
C20H20N8O4S
Molecular Weight:
468.49
COA:
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Targets:
c-Met/HGFR
Description:
PF-04217903 methanesulfonate is a selective ATP-competitive c-Met inhibitor and is susceptible to oncogenic mutations (no activity to Y1230C mutant). It showed more than 1000-fold greater selectivity against c-Met kinase over 150 other kinases. It displays similar potency to inhibit the activity of c-Met-H1094R, c-Met-R988C, and c-Met-T1010I, but has no inhibitory activity against c-Met-Y1230C. It showed antitumor activity in tumor models where c-Met is activated by mechanisms including c-Met gene amplification, HGF/c-Met autocrine loop formation or c-Met overexpression. It suppressed proliferation of c-Met-amplified GTL-16 and H1993cells. It induced apoptosis in GTL-16 cells. It inhibited the phosphorylation of c-Met and suppressed tumor growth.
Purity:
>98%
Synonyms:
PF-04217903 methanesulfonate; PF 04217903 methanesulfonate; PF04217903 methanesulfonate
MSDS:
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InChIKey:
HBEMHKVWZJTVOC-UHFFFAOYSA-N
InChI:
InChI=1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4)
Canonical SMILES:
CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
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CAS 956906-93-7 PF-04217903 methanesulfonate

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