Peramivir - CAS 330600-85-6
Catalog number: 330600-85-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Influenza Virus
Peramivir is an antiviral inhibitor, preventing viruses from infected cells with an IC50 of median 0.09 nM.
White to Off-White Solid
BCX 1812; BCX1812; BCX-1812 (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic Acid
Soluble in DMSO
Store at -20 °C
A new antiviral agent for influenza treatment, could be used as neuraminidase inhibitor for treating human and avian influenza.
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
170-172 °C
1.39 g/cm3
Canonical SMILES:
Current Developer:
BioCryst Pharmaceuticals
1.[Analysis of the Neuraminidase Amino Acid Sequences of Influenza A/H1N1pdm09, A/H3N2, and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season].
Ikematsu H, Chong Y, Shirane K, Toh H, Sasaki H, Koga Y, Matsumoto S, Hotta T, Uchiumi T, Kang D. Fukuoka Igaku Zasshi. 2015 Aug;106(8):231-9.
BACKGROUND: Neuraminidase (NA) is an essential surface protein for influenza virus replication. NA inhibitors are commonly used for the treatment of influenza patients in Japan. Several mutations that reduce the effect of NA inhibitors have been reported. We sequenced the whole NA segment of isolated virus from influenza patients and investigated the relation between the NA amino acid sequence and the 50% inhibitory concentration (IC50) of four NA inhibitors.
2.Effects of corticosteroid and neuraminidase inhibitors on survival in patients with respiratory distress induced by influenza virus.
Huang SF1, Fung CP2, Perng DW3, Wang FD4. J Microbiol Immunol Infect. 2015 Sep 9. pii: S1684-1182(15)00839-7. doi: 10.1016/j.jmii.2015.08.016. [Epub ahead of print]
BACKGROUND/PURPOSE: Neuraminidase inhibitors (NAIs) including oseltamivir and peramivir are used for influenza treatment. A systemic corticosteroid is usually administrated for acute respiratory distress syndrome. The aim of this study was to investigate the effect of a systemic corticosteroid and its interaction with NAIs in patients with influenza infection and respiratory distress.
3.Efficacy of oseltamivir-peramivir combination therapy compared to oseltamivir monotherapy for Influenza A (H7N9) infection: a retrospective study.
Zhang Y1, Gao H2, Liang W3, Tang L4, Yang Y5, Wu X6, Yu L7, Chen P8, Zheng S9, Ou H10, Li L11. BMC Infect Dis. 2016 Feb 10;16(1):76. doi: 10.1186/s12879-016-1383-8.
BACKGROUND: Since the novel H7N9 avian influenza outbreak occurred in China in 2013, neuraminidase inhibitors (NAIs) such as oseltamivir and peramivir have been used as first-line drugs to treat the influenza virus infection. This study aimed to compare the efficacy of oseltamivir-peramivir combination therapy versus oseltamivir monotherapy.
4.A Case of Influenza Associated Fulminant Myocarditis Successfully Treated with Intravenous Peramivir.
Baik SH1, Jeong HS1, Kim SJ2, Yoon YK3, Sohn JW3, Kim MJ3. Infect Chemother. 2015 Dec;47(4):272-7. doi: 10.3947/ic.2015.47.4.272. Epub 2015 Dec 30.
We report the case of a patient with fulminant myocarditis caused by influenza A virus, who presented with acute-onset heart failure and cardiogenic shock and was treated successfully with single dose of intravenous peramivir and with pharmacologic hemodynamic support. A 45-year-old Korean woman presented to our emergency department (ED) with shortness of breath and an episode of seizure that developed abruptly 5 hours before she arrived in the ED. She had a history of recurrent epileptic seizure 25 years ago, but denied other specific medical illnesses. In the ED, she was hypoxemic (arterial partial pressure of oxygen, 59.8 mmHg on room air) and chest radiography revealed bilateral alveolar infiltrates. A rapid antigen test for influenza A virus was positive, and she was administered a single dose of peramivir (300 mg) intravenously. Five hours later, the patient's dyspnea had worsened and she was hypotensive (blood pressure, 86/53 mmHg), requiring norepinephrine infusion.
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CAS 330600-85-6 Peramivir

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