Pentagalloylglucose - CAS 14937-32-7
Catalog number: 14937-32-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C41H32O26
Molecular Weight:
940.68
COA:
Inquire
Targets:
Interleukin Related
Description:
Pentagalloylglucose, a polyphenol isolated from the fruits of Pistacia lentiscus, increases a population of Treg cells in conjunction with Treg-inducing factors so that it inhibites IgE production partially. Besides, it suppresses interleukin (IL)-4 induc
Purity:
>98%
Appearance:
Grey solid
Synonyms:
Pentagalloylglucose; DB-03208; DB 03208; DB03208; [(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate1,2,3,4,6-penta-O-galloyl beta-glucopyranose1,2,3,4,6-penta-O-galloyl-beta-D-glucose1,2,3,4,6-penta-O-galloylglucose1,2,3,4,6-pentagalloylglucose
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -38℃ for long term (months to years).
MSDS:
Inquire
Application:
Anti-tumor/anti-bacterial
Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
1365.7±65.0 °C | Condition: Press: 760 Torr
Melting Point:
143 °C
Density:
2.05±0.1 g/cm3
InChIKey:
QJYNZEYHSMRWBK-NIKIMHBISA-N
InChI:
1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-
Canonical SMILES:
C1=C(C=C(C(=C1O)O)O)C(=O)OCC2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O
1.Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial.
Vansteenkiste JF1, Cho BC2, Vanakesa T3, De Pas T4, Zielinski M5, Kim MS6, Jassem J7, Yoshimura M8, Dahabreh J9, Nakayama H10, Havel L11, Kondo H12, Mitsudomi T13, Zarogoulidis K14, Gladkov OA15, Udud K16, Tada H17, Hoffman H18, Bugge A19, Taylor P20, Gon Lancet Oncol. 2016 Apr 27. pii: S1470-2045(16)00099-1. doi: 10.1016/S1470-2045(16)00099-1. [Epub ahead of print]
BACKGROUND: Fewer than half of the patients with completely resected non-small-cell lung cancer (NSCLC) are cured. Since the introduction of adjuvant chemotherapy in 2004, no substantial progress has been made in adjuvant treatment. We aimed to assess the efficacy of the MAGE-A3 cancer immunotherapeutic in surgically resected NSCLC.
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