Penduletin - CAS 569-80-2
Catalog number: 569-80-2
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H16O7
Molecular Weight:
344.3
COA:
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Chemical Family:
Flavonoids
Description:
Penduletin isolated from the leaves of Laggera pterodonta. It significantly reduces the production of TGF-β1, and has strong activity against EV71 who has low cytotoxicity in vitro.
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Purity:
0.98
Appearance:
Yellow powder
Synonyms:
3,6,7-Trimethyl-6-hydroxykaempferol; 5-hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxychromen-4-one
MSDS:
Inquire
Application:
antiviral; antitumor cells activity
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
Density:
1.45g/cm3
1.2-Phenylindole-linked [2-(aminoalkyl)pyridine]dichloroplatinum(II): complexes with a selective action on estrogen receptor positive mammary tumors.
Knebel NG1, von Angerer E. J Med Chem. 1991 Jul;34(7):2145-52.
A number of [2-(aminomethyl)pyridine]dichloroplatinum(II) complexes, linked to 5-hydroxy-2-(4-hydroxyphenyl)indoles by alkyl spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor. Their relative binding affinity (RBA) values ranged from 1.0 to 5.2% (estradiol, RBA = 100%). Highest affinities were found with complexes possessing a (CH2)5- or (CH2)6-bridge between the pyridine aminomethyl group and the indole nitrogen. Endocrine activities of the complexes and their ligands, determined in the mouse uterine weight test, were low. All compounds entered comparative tests using estrogen receptor positive and negative mammary tumor models. In cell culture, a growth inhibiting effect was only observed in hormone-sensitive MCF-7 cells, but not in hormone-independent MDA-MB 231 cells. In this assay, there was no significant difference between complexes and their ligands. In vivo, the growth of estrogen receptor positive MXT mouse mammary tumors was strongly inhibited by the complexes whereas the hormone-independent MXT mammary tumors showed only a minor response.
2.Structure of 8-(2,6-dideoxy-beta-ribo-hexopyranosyl)-5-hydroxy-2-(4- hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one sesquihydrate, aciculatin
Krause JA1, Eggleston DS. Acta Crystallogr C. 1991 Dec 15;47 ( Pt 12):2595-8.
C22H22O8.1.5H2O, Mr = 441.4, monoclinic, I2, a = 21.037 (7), b = 7.371 (2), c = 27.512 (4) A, beta = 100.34 (2) degrees, V = 4196.8 (8) A3, Z = 8, Dx = 1.397 g cm-3, lambda (Mo K alpha) = 0.71073 A, mu = 1.029 cm-1, F(000) = 1864, T = 295 K, final R (on F) = 0.058 for 2113 observed reflections with I greater than or equal to 2 sigma (I). Aciculatin crystallizes as a sesquihydrate with two independent molecules per asymmetric unit. The 2,6-dideoxy-beta-ribo-hexopyranosyl ring is linked to C8 of the flavone through a beta-C-glycosidic bond. Intramolecular hydrogen bonding occurs between the hydroxyl and ketonic O atoms of the flavone ring system.
3.Platinum complexes with a selective action on estrogen receptor-positive mammary tumors.
von Angerer E1, Birnböck H, Knebel N. Anticancer Drug Des. 1989 Jun;4(1):21-35.
Four (1,3-diaminopropane)dichloroplatinum(II) complexes, linked to 5-hydroxy-2-(4-hydroxyphenyl)-3-methylindole by spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor. The RBA-values ranged from 1.0 to 4.4 (estradiol: RBA = 100). The endocrine activities of the complexes and their ligands, determined in the mouse uterine weight test, are low. All compounds entered comparative tests using estrogen receptor-positive and negative mammary tumors models. The receptor levels in these tumors were determined by a modified h.p.l.c. micro assay. In cell culture, a growth inhibiting effect was only observed in hormone-sensitive MCF-7 cells, but not in hormone-independent MDA-MB-231 cells. At 10(-6) molar, the cell number was generally decreased by 50%. In vivo, the growth of estrogen receptor-positive MXT mouse tumors was strongly inhibited whereas the hormone-independent MXT mammary tumors showed only a minor response.
4.Phenolic compounds from the aqueous extract of Acacia catechu.
Li XC1, Liu C, Yang LX, Chen RY. J Asian Nat Prod Res. 2011 Sep;13(9):826-30. doi: 10.1080/10286020.2011.597384.
Two new phenolic compounds, 5-hydroxy-2-[2-(4-hydroxyphenyl) acetyl]-3-methoxylbenzoic acid (1) and (2S,3S)-3,7,8,3',4'-pentahydroxyflavane (2), were obtained from the aqueous extract of Acacia catechu, along with four known compounds identified as rhamnetin (3), 4-hydroxyphenyl ethanol (4), 3,3',5,5',7-pentahydroxyflavane (5), and fisetinidol (6). Their structures were determined on the basis of spectroscopic analysis. Free radical-scavenging activities of the new compounds were evaluated.
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CAS 569-80-2 Penduletin

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