|Targets||PDK-1 | PI3K|
|Description||PDK1 inhibitor 2610 is an ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB, respectively).|
|Brife Description||dual PI3K and PDPK1 inhibitor|
BX795 is a potent and selective inhibitor of PDK1, IKKε and TBK1, which regulates the production of Type 1 interferons during bacterial and viral infection. BX7...
Quercetin is a flavonoid found in galangal and is used as an antitumor agent that induces apoptosis of cancer cells. It acts as a PI 3-kinase and protein kinase...
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.
TEPP-46, an effective sensitizer of recombinant pyruvate kinase M2, has been found to decrease the formation of tumor in a mouse xenograft model. IC50: 92 nM (A...
LY 294002 hydrochloride
LY 294002 hydrochloride is a PI 3-kinase inhibitor with IC50 values of 0.31μM for PI 3-Kβ, 0.73μM for PI 3-Kα, 1.06μM for PI 3-Kδ and 6.60μM for PI 3-Kγ. It can...
TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has antiproliferat...
AS-252424 is a novel, potent PI3Kγ inhibitor (IC50 of 30 nM) with a 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β.
PS 47 is an inactive E-isomer of the PDK1 activator PS 48. In combination with PS 48, PS 47 can be used as a negative control.