Panaxatriol - CAS 32791-84-7
Catalog number: B0005-465159
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H52O4
Molecular Weight:
476.73
COA:
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Chemical Family:
Triterpenoids
Description:
Panaxatriol, a natural product extracted from the roots of Panax ginseng C. A. Mey, with significant antiradiation effects it can relieve myelosuppression induced by radiation injury. It ameliorates I/R-induced myocardial damage by reducing oxidative stre
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-465159 50mg $189 In stock
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Purity:
>98%
Appearance:
White powder
Synonyms:
Dammarane-3,6,12-triol, 20,25-epoxy-,(3β,6β,12β,20R)-;Panoxatriol;(20R)-20,25-Epoxy-5α-dammarane-3β,6α,12β-triol;panaxatriol, (3beta,6alpha,12beta)-isomer
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -91℃ for long term (months to years).
MSDS:
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Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Milligrams-Grams
Boiling Point:
561.5±50.0 °C | Condition: Press: 760 Torr
Melting Point:
238-239 °C
Density:
1.068±0.06 g/cm3
InChIKey:
QFJUYMMIBFBOJY-UXZRXANASA-N
InChI:
1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1
Canonical SMILES:
CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CC(C5C4(CCC(C5(C)C)O)C)O)C)O)C)C
1.Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. I. Chemical part.
Kaku T;Miyata T;Uruno T;Sako I;Kinoshita A Arzneimittelforschung. 1975 Mar;25(3):343-7.
For the purpose of clarification of pharmacological actions of ginseng saponins we tried the isolation of ginseng saponins on a larger scale and succeeded in the isolation of eight saponins in a pure state and in sufficient amounts for the pharmacological assay. These eight saponins agreed all completely with the authentic samples of Shibata-Shoji and co-workers in molecular formula of saponins and sapogenins, sugars and TLC. The physical properties of saponins were shown. As other components of ginseng, there were isolated small amounts of panaxadiol, panaxatriol, daucosterol from the first running of column chromatography and mannitol, sucrose and glucose from the ethanol insoluble aqueous extract.
2.[Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from Ginseng and Sea cucumber].
Popov AM Izv Akad Nauk Ser Biol. 2002 Mar-Apr;(2):155-64.
Specific features of cytotoxic (against tumor cells), hemolytic, and liposomal (effect on permeability) activities of triterpenoids isolated from sea cucumbers and ginseng roots were studied. It was shown that oleanolic acid, protopanaxatriol, and protopanaxadiol at 5 to 20 micrograms/ml inhibited the growth of tumor cells, while at doses up to 100 micrograms/ml, they did not induce hemolysis or changes in liposome permeability. Monoglucosides of protopanaxadiol, Rh2, Rg3, and substance K exerted moderate cytotoxic and membrane activities. The membrane sensitivity to these glucosides was inversely proportional to the membrane content of cholesterol. The cytotoxicity of the protopanaxadiol-active glycosides increased with a decrease of pH of the medium. All studied glycosides did not affect the cell and model lipid membranes. The activity of the oleanolic acid glycoside, ginsenoside Z-R1, depended to a great extent on the pH of the medium. The decrease of pH from 7.4 to 5.6 increased the membranolytic activities by more than one order of magnitude. Glycosides from sea cucumbers, echinosides A and B, holothurins A and B, holotoxin A1, and cucumarioside G1, had very high cytotoxic and liposomal activities.
3.Effect of ginseng saponins on the recombinant serotonin type 3A receptor expressed in xenopus oocytes: implication of possible application as an antiemetic.
Min KT;Koo BN;Kang JW;Bai SJ;Ko SR;Cho ZH J Altern Complement Med. 2003 Aug;9(4):505-10.
OBJECTIVES: ;Nausea and vomiting are the most frequently reported side-effects by patients who are given general anesthesia perioperatively and patients with cancer who undergo chemotherapy or radiotherapy. Serotonin (5-hydroxytryptamine, 5HT) type 3A receptor (5HT(3A) receptor) is known to mediate nausea and vomiting and its antagonists have been used effectively to prevent and/or reduce the incidence and severity of nausea and vomiting. However, the adverse effects on cardiac function, such as QT interval prolongation, limit their routine use by these patients. This study was designed to elucidate the effect of ginseng saponins on the recombinant 5HT(3A) receptor expressed in the xenopus oocyte.;DESIGN: ;After in vitro transcription of the recombinant human 5HT(3A) receptor in the Xenopus laevis oocyte, we examined Panax ginseng saponins (total saponin [TS], panaxadiol saponin [PD] fraction, panaxatriol saponin [PT] fraction, and ginsenoside-Rb1 and -Rg1) for their ability to inhibit current flow through the 5HT(3A) receptor using the voltage-clamp technique.;RESULTS: ;All saponin fractions (TS, PD, PT fraction, as well as ginsenoside-Rb1 and -Rg1) inhibited the peak current induced by the agonist 5HT on the 5HT(3A) receptor in a concentration-dependent, reversible, and voltage-independent manner.
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CAS 32791-84-7 Panaxatriol

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