Palustrol - CAS 5986-49-2
Catalog number: 5986-49-2
Not Intended for Therapeutic Use. For research use only.
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1.Isolation, antimicrobial and antitumor activities of a new polyhydroxysteroid and a new diterpenoid from the soft coral Xenia umbellata.
Ayyad SN;Alarif WM;Al-Footy KO;Selim EA;Ghandourah MA;Aly MM;Alorfi HS Z Naturforsch C. 2017 Jan 1;72(1-2):27-34. doi: 10.1515/znc-2015-0228.
A new C-30 steroid, 3β-,5α-,6β-,11α-,20β-pentahydroxygorgosterol (1), and a new diterpenoid, xeniumbellal (2), along with three known aromadendrane-type sesquiterpenes, aromadendrene (3), palustrol (4) and viridiflorol (5), were isolated from the soft coral Xenia umbellata. Chemical structures were determined by analyzing their NMR and MS data. The antimicrobial and antitumor activities of the isolated compounds were examined. Both 1 and 2 showed moderate antibacterial activities, especially against the multidrug-resistant Acinetobacter baumannii (MIC 0.22 and 0.28 mM, respectively); while 2 showed antitumor activity against a lymphoma cell line with LD50 0.57 mM and was nontoxic to Artemia salina at all tested concentrations up to about 4 mM.
2.Composition of the essential oil of the Rhododendron tomentosum Harmaja from Estonia.
Raal A;Orav A;Gretchushnikova T Nat Prod Res. 2014;28(14):1091-8. doi: 10.1080/14786419.2014.907287. Epub 2014 Apr 9.
Wild Rhododendron tomentosum Harmaja shoots were collected from four localities of Estonia. Essential oils, isolated from dried samples by simultaneous distillation and extraction, were analysed using GC-FID and Gas chromatography-mass spectrometry methods. The yields of oils were in the range 0.14-0.87%. A total of 72 constituents, accounting for over 95% of the total oil yield, were identified. The major components in the all four oils studied were palustrol (15.9-53.5%), ledol (11.8-18.3%), γ-terpineol (0-31.2%), p-cymene (0.1-13.9%), lepalone (0.7-6.5%), lepalol (1.0-6.5%) and cyclocolorenone (1.0-6.4%). Two different chemotypes of R. tomentosum were found in Estonia and one of them was rich in palustrol (41.0-53.5%) and ledol (14.6-18.3%). The second chemotype, for the first time, was rich in γ-terpineol (24.7-31.2%) and contained less of palustrol (15.9-16.7%) and ledol (11.8-12.8%), but more p-cymene (12.5-13.9%). Also, γ-terpineol was identified for the first time in the oils of R. tomentosum.
3.Seasonal variation of the essential oil from two Brazilian native Aldama La Llave (Asteraceae) species.
Oliveira TS;Bombo AB;Oliveira AS;Garcia VL;Appezzato-DA-Glória B An Acad Bras Cienc. 2016;88(3 Suppl):1899-1907. doi: 10.1590/0001-376520162015-0732. Epub 2016 Nov 10.
Aldama arenaria and A. robusta are morphologically similar aromatic species that have seasonal development. The yield and chemical composition of essential oils from aerial and underground vegetative organs of these species were compared to verify the production of volatile metabolites in flowering and dormant phases of development and to identify if there are unique compounds for either species. The major compound in the essential oils from A. arenaria leaves was palustrol (16.22%) and for aerial stems was limonene (15.3%), whereas limonene (11.16%) and α-pinene (19.64%) were the major compounds for leaves and aerial stems from A. robusta, respectively. The major compound for the underground organs was α-pinene, in both species and phenological stages. High amounts of diterpenes were found especially for A. arenaria essential oils. Each analyzed species presented unique compounds, which can provide a characteristic chemical profile for both species helping to solve their taxonomic problems. This study characterized for the first time the yield and essential oil composition of A. arenaria and A. robusta, which have medicinal potential, and some of the compounds in their essential oils are unique to each one and may be useful in helping the correct identification of them.
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CAS 5986-49-2 Palustrol

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