Palladium diacetate - CAS 3375-31-3
Catalog number: 3375-31-3
Category: Intermediates
Molecular Formula:
Pd.(C2H3O2)2
Molecular Weight:
224.51
COA:
Inquire
Purity:
98%
Appearance:
brown needles
Synonyms:
ACETIC ACID PALLADIUM(II) SALT; PALLADIUM ACETATE; PALLADIUM(+2)ACETATE; PALLADIUM DIACETATE; PALLADIUM(II) ACETATE; PALLADIUM(II) ACETATE IN IONIC LIQUID ON SILICA
Storage:
Store at R.T.
MSDS:
Inquire
Quantity:
Data not available, please inquire.
Boiling Point:
117.1ºC at 760mmHg
Melting Point:
205ºC
Density:
g/cm3
InChIKey:
YJVFFLUZDVXJQI-UHFFFAOYSA-L
InChI:
InChI=1S/2C2H4O2.Pd/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
Canonical SMILES:
CC(=O)[O-].CC(=O)[O-].[Pd+2]
Physical Description:
Palladium(II) acetate 47.5% Pd (10g)
1.Biochemical and proteomic analysis of a potential anticancer agent: Palladium(II) Saccharinate complex of terpyridine acting through double strand break formation.
Adiguzel Z1, Baykal AT, Kacar O, Yilmaz VT, Ulukaya E, Acilan C. J Proteome Res. 2014 Nov 7;13(11):5240-9. doi: 10.1021/pr5006718. Epub 2014 Sep 11.
Metal based chemotherapeutic drugs are widely used as an effective method to defeat various cancers. In this study, the mechanism of action of a novel therapeutic agent, [Pd(sac)(terpy)](sac)·4H2O (sac = saccharinate, and terpy = 2,2':6',2″-terpyridine) was studied. To better understand the proteomic changes in response to this agent, we performed nano LC-MS/MS analyses in human breast cancer cells (MDA-MB-231). Thirty proteins were identified to be differentially expressed more than 40% after drug treatment. Many cellular pathways were affected, including proteins involved in DNA repair, apoptosis, energy metabolism, protein folding, cytoskeleton, pre-mRNA maturation, or protein translation. The changes in protein expression were further verified for XRCC5, which plays a role in double strand break (DSB) repair, and ubiquitin, which is involved in protein degradation and apoptosis. The elevated XRCC5 levels were suggestive of increased DSBs.
2.Regioselective hydrothiolation of alkenes bearing heteroatoms with thiols catalyzed by palladium diacetate.
Tamai T1, Ogawa A. J Org Chem. 2014 Jun 6;79(11):5028-35. doi: 10.1021/jo500586a. Epub 2014 May 13.
In sharp contrast to many examples of transition-metal-catalyzed hydrothiolation of alkynes, the corresponding catalytic addition of thiols to alkenes has remained undeveloped. However, a novel Pd-catalyzed addition of thiols to alkenes bearing a heteroatom, such as oxygen and nitrogen, is found to proceed under mild conditions to give the corresponding Markovnikov adducts, regioselectively, in good yields.
3.Palladium-Catalyzed Synthesis of α-Diimines from Triarylbismuthines and Isocyanides.
Kobiki Y1, Kawaguchi S1, Ogawa A1. Org Lett. 2015 Jul 17;17(14):3490-3. doi: 10.1021/acs.orglett.5b01566. Epub 2015 Jul 8.
In this study, we report a highly selective coupling reaction between triarylbismuthines and isocyanides using palladium diacetate as the catalyst, affording α-diimines, with the formation of three C-C bonds. Among several aryl sources (Ar-YLn: Y = B, Sn, Pb, Sb, Bi, I), only triarylbismuthines successfully undergo coupling with isocyanides to selectively afford α-diimines. The coupling reaction exhibits the advantages of high atom economy and convenient operation, with no need for any additive.
4.Theoretical Studies on Palladium-Mediated Enantioselective C-H Iodination.
Zhou MJ1, Yang TL1, Dang L1. J Org Chem. 2016 Feb 5;81(3):1006-20. doi: 10.1021/acs.joc.5b02571. Epub 2016 Jan 26.
DFT calculations have been carried out to investigate the reaction mechanism for Pd(II)-mediated enantioselective C-H iodination. Iodination of the aryl ortho C-H bond of benzylamines catalyzed by Pd(II) diacetate complexes in the presence of the L-MPAA ligand experiences three main steps: first, C-H bond activation; second, oxidative addition of iodine on Pd(II) and reductive elimination of iodobenzene; third, catalyst regeneration through ligand exchange. The C-H bond activation is found to be the rate-determining step of the overall iodination due to higher activation energy. The reaction barrier for the formation of iodinated (R)-benzylamine is lower than that of (S)-benzylamine, which confirms the R enantioselectivity in iodination at room temperature. The retainment of the coordination of one acetic acid on Pd(II) and the chelating MPAA ligand during the catalyzed reaction are suggested to give space economy to facilitate the C-H bond activation.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


Chemical Structure

CAS 3375-31-3 Palladium diacetate

Quick Inquiry

Verification code

Featured Items