p-Hydroxycinnamic acid - CAS 7400-08-0
Catalog number: 7400-08-0
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Chemical Family:
Phenylpropanoids, The barks of Cinnamomum cassia Presl
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(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid; 4-hydroxycinnamic acid; 3-(4-Hydroxyphenyl)acrylic acid
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1.Characterization of a Citrus R2R3-MYB Transcription Factor that Regulates the Flavonol and Hydroxycinnamic Acid Biosynthesis.
Liu C;Long J;Zhu K;Liu L;Yang W;Zhang H;Li L;Xu Q;Deng X Sci Rep. 2016 May 10;6:25352. doi: 10.1038/srep25352.
Flavonols and hydroxycinnamic acids are important phenylpropanoid metabolites in plants. In this study, we isolated and characterized a citrus R2R3-MYB transcription factor CsMYBF1, encoding a protein belonging to the flavonol-specific MYB subgroup. Ectopic expression of CsMYBF1 in tomato led to an up-regulation of a series of genes involved in primary metabolism and the phenylpropanoid pathway, and induced a strong accumulation of hydroxycinnamic acid compounds but not the flavonols. The RNAi suppression of CsMYBF1 in citrus callus caused a down-regulation of many phenylpropanoid pathway genes and reduced the contents of hydroxycinnamic acids and flavonols. Transactivation assays indicated that CsMYBF1 activated several promoters of phenylpropanoid pathway genes in tomato and citrus. Interestingly, CsMYBF1 could activate the CHS gene promoter in citrus, but not in tomato. Further examinations revealed that the MYBPLANT cis-elements were essential for CsMYBF1 in activating phenylpropanoid pathway genes.
2.Stress-responsive hydroxycinnamate glycosyltransferase modulates phenylpropanoid metabolism in Populus.
Babst BA;Chen HY;Wang HQ;Payyavula RS;Thomas TP;Harding SA;Tsai CJ J Exp Bot. 2014 Aug;65(15):4191-200. doi: 10.1093/jxb/eru192. Epub 2014 May 6.
The diversity of phenylpropanoids offers a rich inventory of bioactive chemicals that can be exploited for plant improvement and human health. Recent evidence suggests that glycosylation may play a role in the partitioning of phenylpropanoid precursors for a variety of downstream uses. This work reports the functional characterization of a stress-responsive glycosyltransferase, GT1-316 in Populus. GT1-316 belongs to the UGT84A subfamily of plant glycosyltransferase family 1 and is designated UGT84A17. Recombinant protein analysis showed that UGT84A17 is a hydroxycinnamate glycosyltransferase and able to accept a range of unsubstituted and substituted cinnamic and benzoic acids as substrates in vitro. Overexpression of GT1-316 in transgenic Populus led to plant-wide increases of hydroxycinnamoyl-glucose esters, which were further elevated under N-limiting conditions. Levels of the two most abundant flavonoid glycosides, rutin and kaempferol-3-O-rutinoside, decreased, while levels of other less abundant flavonoid and phenylpropanoid conjugates increased in leaves of the GT1-316-overexpressing plants.
3.Inhibitor analysis and adaptive evolution of Saccharomyces cerevisiae for simultaneous saccharification and ethanol fermentation from industrial waste corncob residues.
Gu H;Zhang J;Bao J Bioresour Technol. 2014 Apr;157:6-13. doi: 10.1016/j.biortech.2014.01.060. Epub 2014 Feb 1.
Industrial waste corncob residues (CCR) are rich in cellulose and can be hydrolyzed directly without pretreatment. However, a poor fermentation performance was frequently observed in the simultaneous saccharification and ethanol fermentation (SSF) of CCR, although the furans and organic acid inhibitors were very low. In this study, the high level of water-insoluble phenolic compounds such as 2-furoic acid, ferulic acid, p-coumaric acid, guaiacol, and p-hydroxybenzoic acid were detected in CCR and inhibited the growth and metabolism of Saccharomyces cerevisiae DQ1. An evolutionary adaptation strategy was developed by culturing the S. cerevisiae DQ1 strain in a series of media with the gradual increase of CCR hydrolysate. The high ethanol concentration (62.68g/L) and the yield (55.7%) were achieved in the SSF of CCR using the adapted S. cerevisiae DQ1. The results provided a practical method for improving performance of simultaneous saccharification and ethanol production from CCR.
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CAS 7400-08-0 p-Hydroxycinnamic acid

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