Oxybutynin chloride - CAS 1508-65-2
Catalog number: 1508-65-2
Category: Inhibitor
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Molecular Formula:
C22H31NO3.HCl
Molecular Weight:
393.95
COA:
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Targets:
mAChR
Description:
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
Purity:
>98%
Synonyms:
Oxybutynin Hydrochloride; Oxybutynin HCl
MSDS:
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InChIKey:
SWIJYDAEGSIQPZ-UHFFFAOYSA-N
InChI:
InChI=1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H
Canonical SMILES:
CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.Cl
1.Preformulation studies on the S-isomer of oxybutynin hydrochloride, an Improved Chemical Entity (ICE).
Luner PE1, Kirsch LE, Majuru S, Oh E, Joshi AB, Wurster DE, Redmon MP. Drug Dev Ind Pharm. 2001 Apr;27(4):321-9.
(S)-Oxybutynin HCl (S-OXY) is a white crystalline solid powder with an acicular particle morphology. Differential scanning calorimetry (DSC) thermograms revealed one characteristic endotherm at 116.2 degrees C. On rescanning a sample heated to 120 degrees C, no thermal events were distinguished in the temperature range 25 degrees C to 150 degrees C. Weight loss curves determined by thermogravimetric analysis showed a continuous, gradual weight loss of about 0.15% over the temperature range 30 degrees C to 110 degrees C, followed by a change in slope and more rapid weight loss beginning at 150 degrees C. Observation by hot-stage microscopy confirmed the melting endotherm observed by DSC. Equilibrium moisture uptake studies indicated low water vapor uptake at low relative humidities (<52.8%). At relative humidities of 75.3% and 84.3%, S-OXY first deliquesced and then converted to a lower melting point crystal form. X-ray powder diffraction (XRPD) data supported the DSC findings.
2.An update on the use of transdermal oxybutynin in the management of overactive bladder disorder.
Cohn JA1, Brown ET2, Reynolds WS2, Kaufman MR2, Milam DF2, Dmochowski RR2. Ther Adv Urol. 2016 Apr;8(2):83-90. doi: 10.1177/1756287215626312. Epub 2016 Jan 19.
Antimuscarinic medications are used to treat nonneurogenic overactive bladder refractory to nonpharmacologic therapy. Side effects such as dry mouth, constipation, blurred vision, dizziness, and impaired cognition limit the tolerability of therapy and are largely responsible for high discontinuation rates. Oxybutynin is a potent muscarinic receptor antagonist whose primary metabolite after first-pass hepatic metabolism is considered largely responsible for its associated anticholinergic side effects. Transdermal administration of medications bypasses hepatic processing. Specifically with oxybutynin, whose low molecular weight permits transdermal administration, bioavailability of the parent drug with oral administration is less than 10%, whereas with transdermal delivery is a minimum of 80%. The result has been an improved side effect profile in multiple clinical trials with maintained efficacy relative to placebo; however, the drug may still be discontinued by patients due to anticholinergic side effects and application site reactions.
3.Effectiveness of oxybutynin hydrochloride in the treatment of enuresis nocturna--a clinical and urodynamic study.
Koşar A1, Arikan N, Dinçel C. Scand J Urol Nephrol. 1999 Apr;33(2):115-8.
OBJECTIVE: To find the efficacy and optimal dosage of oxybutynin HC1 in a group of enuretic children, who were non-responsive to imipramine.
4.Inhibitory effects of propiverine, atropine and oxybutynin on bladder instability in rats with infravesical outlet obstruction.
Kwak TI1, Lee JG. Br J Urol. 1998 Aug;82(2):272-7.
OBJECTIVE: To compare the inhibitory effects of propiverine HCl(BUP-4) with those of atropine and oxybutynin on the detrusor instability induced by partial obstruction of the bladder neck of female rats.
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CAS 1508-65-2 Oxybutynin chloride

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