Oxybutynin - CAS 5633-20-5
Catalog number: 5633-20-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
Canonical SMILES:
1.The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats.
Wróbel A1, Rechberger T2. Urology. 2016 Mar 23. pii: S0090-4295(16)00296-X. doi: 10.1016/j.urology.2016.03.008. [Epub ahead of print]
OBJECTIVES: To test the hypothesis that maxacalcitol, vitamin D3 analog, would ameliorate detrusor overactivity (DO) induced by retinyl acetate instillation; To test the outcome of the combined administration of maxacalcitol and the ROCK inhibitor -GSK 269962, amlodipine besylate or oxybutynin chloride in this model.
2.Electrical stimulation with non-implanted electrodes for overactive bladder in adults.
Stewart F1, Gameiro OL, El Dib R, Gameiro MO, Kapoor A, Amaro JL. Cochrane Database Syst Rev. 2016 Apr 2;4:CD010098. [Epub ahead of print]
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency.
3.An update on the use of transdermal oxybutynin in the management of overactive bladder disorder.
Cohn JA1, Brown ET2, Reynolds WS2, Kaufman MR2, Milam DF2, Dmochowski RR2. Ther Adv Urol. 2016 Apr;8(2):83-90. doi: 10.1177/1756287215626312. Epub 2016 Jan 19.
Antimuscarinic medications are used to treat nonneurogenic overactive bladder refractory to nonpharmacologic therapy. Side effects such as dry mouth, constipation, blurred vision, dizziness, and impaired cognition limit the tolerability of therapy and are largely responsible for high discontinuation rates. Oxybutynin is a potent muscarinic receptor antagonist whose primary metabolite after first-pass hepatic metabolism is considered largely responsible for its associated anticholinergic side effects. Transdermal administration of medications bypasses hepatic processing. Specifically with oxybutynin, whose low molecular weight permits transdermal administration, bioavailability of the parent drug with oral administration is less than 10%, whereas with transdermal delivery is a minimum of 80%. The result has been an improved side effect profile in multiple clinical trials with maintained efficacy relative to placebo; however, the drug may still be discontinued by patients due to anticholinergic side effects and application site reactions.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mAChR Products

CAS 1952-15-4 4-DAMP

(CAS: 1952-15-4)

4-DAMP is a potent and selective antagonist of the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Blockade of mAChR M2 leads to a ...

CAS 203321-88-4 MK-0969

(CAS: 203321-88-4)

MK-0969 is an Muscarinic M3 antagonist which has the potential for the treatment of chronic obstructive pulmonary diseases.

CAS 5892-41-1 Camylofine dihydrochloride

Camylofine dihydrochloride
(CAS: 5892-41-1)

Camylofine dihydrochloride is the salt form of Camylofine. Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle acti...

CAS 120241-31-8 Alvameline

(CAS: 120241-31-8)

Alvameline, also known as Lu25-109, is a partial M1agonist and M2/M3antagonist that was progressed into clinical studies for the treatment of Alzheimer's diseas...

CAS 3485-62-9 Clidinium Bromide

Clidinium Bromide
(CAS: 3485-62-9)

Clidinium bromide is an anticholinergic used as an antispasmodic to reduce stomach acid and decreases intestinal spasms.

CAS 1197-60-0 5-Methylfurmethiodide

(CAS: 1197-60-0)

5-Methylfurmethiodide is a selective muscarinic agonist in mammals.

CAS 54-71-7 Pilocarpine Hydrochloride

Pilocarpine Hydrochloride
(CAS: 54-71-7)

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

CAS 1135242-13-5 VU 0357017 hydrochloride

VU 0357017 hydrochloride
(CAS: 1135242-13-5)

The hydrochloride salt form of VU0357017 which is a selective M1 agonists and has been found to be probably effective in the treatment of hippocampal-dependent ...

Chemical Structure

CAS 5633-20-5 Oxybutynin

Quick Inquiry

Verification code

Featured Items