Oxybutynin - CAS 5633-20-5
Catalog number: 5633-20-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
Canonical SMILES:
1.The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats.
Wróbel A1, Rechberger T2. Urology. 2016 Mar 23. pii: S0090-4295(16)00296-X. doi: 10.1016/j.urology.2016.03.008. [Epub ahead of print]
OBJECTIVES: To test the hypothesis that maxacalcitol, vitamin D3 analog, would ameliorate detrusor overactivity (DO) induced by retinyl acetate instillation; To test the outcome of the combined administration of maxacalcitol and the ROCK inhibitor -GSK 269962, amlodipine besylate or oxybutynin chloride in this model.
2.Electrical stimulation with non-implanted electrodes for overactive bladder in adults.
Stewart F1, Gameiro OL, El Dib R, Gameiro MO, Kapoor A, Amaro JL. Cochrane Database Syst Rev. 2016 Apr 2;4:CD010098. [Epub ahead of print]
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency.
3.An update on the use of transdermal oxybutynin in the management of overactive bladder disorder.
Cohn JA1, Brown ET2, Reynolds WS2, Kaufman MR2, Milam DF2, Dmochowski RR2. Ther Adv Urol. 2016 Apr;8(2):83-90. doi: 10.1177/1756287215626312. Epub 2016 Jan 19.
Antimuscarinic medications are used to treat nonneurogenic overactive bladder refractory to nonpharmacologic therapy. Side effects such as dry mouth, constipation, blurred vision, dizziness, and impaired cognition limit the tolerability of therapy and are largely responsible for high discontinuation rates. Oxybutynin is a potent muscarinic receptor antagonist whose primary metabolite after first-pass hepatic metabolism is considered largely responsible for its associated anticholinergic side effects. Transdermal administration of medications bypasses hepatic processing. Specifically with oxybutynin, whose low molecular weight permits transdermal administration, bioavailability of the parent drug with oral administration is less than 10%, whereas with transdermal delivery is a minimum of 80%. The result has been an improved side effect profile in multiple clinical trials with maintained efficacy relative to placebo; however, the drug may still be discontinued by patients due to anticholinergic side effects and application site reactions.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mAChR Products

CAS 22254-24-6 Ipratropium bromide

Ipratropium bromide
(CAS: 22254-24-6)

Ipratropium bromide, under the trade name Atrovent, structurally similar to atropine, is a muscarinic antagonist and a bronchodilator.

CAS 21093-51-6 W-84 dibromide

W-84 dibromide
(CAS: 21093-51-6)

W-84 dibromide is a potent allosteric modulator of muscarinic M2 receptors. W-84 dibromide has been shown to stabilize cholinergic antagonist-receptor complexes...

CAS 201939-40-4 PTAC oxalate

PTAC oxalate
(CAS: 201939-40-4)

PTAC oxalate is a muscarinic receptor ligand, which shows partial agonist activity at the M2 and M4 receptors, with minor antagonistic activity at m1, m3, m5 re...

CAS 107220-28-0 Cevimeline hydrochloride

Cevimeline hydrochloride
(CAS: 107220-28-0)

Cevimeline hydrochloride is a selective M1 receptor agonist.

CAS 127308-98-9 Zamifenacin fumarate

Zamifenacin fumarate
(CAS: 127308-98-9)

Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi = 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors, respectively). Zamifenac...

CAS 149-64-4 Scopolamine butylbromide

Scopolamine butylbromide
(CAS: 149-64-4)

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system. The central effects include hallucinations, disori...

CAS 54-30-8 Camylofine

(CAS: 54-30-8)

Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscl...

CAS 51-56-9 Homatropine Bromide

Homatropine Bromide
(CAS: 51-56-9)

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 1...

Chemical Structure

CAS 5633-20-5 Oxybutynin

Quick Inquiry

Verification code

Featured Items