Oxybutynin - CAS 5633-20-5
Catalog number: 5633-20-5
Category: Inhibitor
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Molecular Formula:
C22H31NO3
Molecular Weight:
357.49
COA:
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Targets:
mAChR
Description:
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
Purity:
>98%
MSDS:
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InChIKey:
XIQVNETUBQGFHX-UHFFFAOYSA-N
InChI:
InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3
Canonical SMILES:
CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
1.The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats.
Wróbel A1, Rechberger T2. Urology. 2016 Mar 23. pii: S0090-4295(16)00296-X. doi: 10.1016/j.urology.2016.03.008. [Epub ahead of print]
OBJECTIVES: To test the hypothesis that maxacalcitol, vitamin D3 analog, would ameliorate detrusor overactivity (DO) induced by retinyl acetate instillation; To test the outcome of the combined administration of maxacalcitol and the ROCK inhibitor -GSK 269962, amlodipine besylate or oxybutynin chloride in this model.
2.Electrical stimulation with non-implanted electrodes for overactive bladder in adults.
Stewart F1, Gameiro OL, El Dib R, Gameiro MO, Kapoor A, Amaro JL. Cochrane Database Syst Rev. 2016 Apr 2;4:CD010098. [Epub ahead of print]
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency.
3.An update on the use of transdermal oxybutynin in the management of overactive bladder disorder.
Cohn JA1, Brown ET2, Reynolds WS2, Kaufman MR2, Milam DF2, Dmochowski RR2. Ther Adv Urol. 2016 Apr;8(2):83-90. doi: 10.1177/1756287215626312. Epub 2016 Jan 19.
Antimuscarinic medications are used to treat nonneurogenic overactive bladder refractory to nonpharmacologic therapy. Side effects such as dry mouth, constipation, blurred vision, dizziness, and impaired cognition limit the tolerability of therapy and are largely responsible for high discontinuation rates. Oxybutynin is a potent muscarinic receptor antagonist whose primary metabolite after first-pass hepatic metabolism is considered largely responsible for its associated anticholinergic side effects. Transdermal administration of medications bypasses hepatic processing. Specifically with oxybutynin, whose low molecular weight permits transdermal administration, bioavailability of the parent drug with oral administration is less than 10%, whereas with transdermal delivery is a minimum of 80%. The result has been an improved side effect profile in multiple clinical trials with maintained efficacy relative to placebo; however, the drug may still be discontinued by patients due to anticholinergic side effects and application site reactions.
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CAS 5633-20-5 Oxybutynin

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