Oxibendazole - CAS 20559-55-1
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Not Intended for Therapeutic Use. For research use only.
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Oxibendazole is a broad-spectrum anthelmintic
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1. Thin-layer chromatography enantioseparations on chiral stationary phases: a review
Massimo Del Bubba & Leonardo Checchini &Luciano Lepri. Anal Bioanal Chem (2013) 405:533–554
Non-commercial MCTA plates have been tested for their quantitative application on a number of racemic compounds by using in situ densitometric detection in the UV region. In most cases good linearity and signal-to-noise ratios higher than 3 were achieved for amounts of each solute applied to the plate as low as 0.1 μg. For example, linear correlation coefficients higher than or equal to 0.990 were obtained for albendazole sulfoxide, chlorbensid sulfoxide and methiocarb sulfoxide applied to the plate in the ranges 0.13-1.31, 0.12-1.22 and 1.31-5.22 μg, respectively. These results suggested the applicability of MCTA-based CSPs to the determination at parts per billion levels of the individual enantiomers of the two pesticides in environmental matrices, and to pharmacokinetic studies of albendazole sulfoxide, even though with lower performances than those achieved using chiral HPLC methods. In this regard, as shown in the thin-layer chromatogram illustrated in Fig. 5 and in the corresponding densitograms in Fig. 6, it is possible to achieve the separation of the two enantiomers of albendazole sulfoxide together with that of albendazole (the reduced achiral precursor of albendazole sulfoxide), albendazole sulfone (the achiral product of further oxidation of albendazole sulfoxide) and oxibendazole (an achiral compound structurally related to albendazole and albendazole derivatives, commonly used as an internal standard in the study of albendazole pharmacokinetics). Thus, these layers have shown chemoselective properties as well as very good enantioselective power.
2. Desorption electrospray ionization-high resolution mass spectrometry for the screening of veterinary drugs in cross-contaminated feedstuffs
Raquel Seró & Oscar Núñez & Jaume Bosch & José M. Grases. Anal Bioanal Chem (2015) 407:7369–7378
Figure 3 shows the DESI-HRMS spectrum of a narasin medicated feed where both narasin and monensin were identified. Additionally, results obtained for non-medicated feed indicated that cross-contamination occurs quite frequently and values above the legislated levels were detected in 28 % of the samples analyzed by DESI-HRMS. Coccidiostats (monensin, narasin, decoquinate, nicarbazin, salinomycin, and lasalocid), benzimidazoles (oxibendazole), amphenicols (florfenicol), tetracyclines (doxycycline and tetracycline), lincosamides (lincomycin), and pleuromutilins (tiamulin) were identified in the non-medicated feed samples at concentrations ranging from 29 to 1.3 μgg−1. For most of these samples, the cross-contamination was at concentrations close to the maximum residue levels, except for sample BF2, where salinomycin was detected at 20 μgg−1, a third of the minimum dose recommended for a medicated feed (60 μgg−1). Furthermore, in most of the non-medicated feeds, several veterinary drugs were detected in the same sample.
3. Population-S benzimidazole- and tetrahydropyrimidine-resistant small strongyles in a pony herd in Kentucky (1977–1999): effects of anthelmintic treatment on the parasites as determined in critical tests
Eugene Lyons. Parasitol Res (2003) 91: 407–411
Population-S benzimidazole-resistant small strongyles have been studied for over 25 years in a closed Shetland pony breeding herd at the University of Kentucky. All of the ponies, except foals, were treated periodically, usually every 8 weeks, with cambendazole (CBZ) from 1974 to 1978 (Drudge et al. 1983), oxibendazole (OBZ) from 1978 to 1992 (Drudge et al. 1985; Lyons et al. 1994), and pyrantel pamoate (PRT) from 1992 to 1999 (Lyons et al. 2001). Resistance of small strongyles to all three anthelmintics was discovered by evaluation of field tests within the breeding herd and in critical tests in yearling and some older ponies. The purposes of this paper include data from critical tests for comparison of criteria used for determining efficacy or effect of several different antiparasitic compounds, particularly OBZ and PRT, on small strongyle species and presentation on changes in species composition of the small strongyles over time. Evaluation of activity of these drugs on small strongyles was by comparison of different parameters encompassing counts of: (1) worms removed and those remaining at necropsy, (2) gravid females passed in feces after treatment and recovered at necropsy, (3) eggs per gram of feces (EPGs) pre- and post treatment, and (4) larvae per gram of feces (LPGs) pre- and post treatment. The female worms were examined for eggs in utero mainly to verify whether EPG data were a ‘‘true indicator’’ of drug efficacy. Historically, some antiparasitic compounds, such as low-level phenothiazine administered to horses, would interfere with strongyle egg production even though it did not remove adult specimens (Dimock 1949; Todd et al. 1950).
4. Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007
E. T. Lyons & S. C. Tolliver & M. Ionita & S. S. Collins. Parasitol Res (2008) 103:287–291
The studies reported here show the value of monitoring horses on farms for indications of changes in activity of parasiticides. This provides current information regarding parasite control in equids, which should be useful for horse owners, equine practitioners, and the scientific community. Field test data showed the highest to lowest ranking of drug activity against ascarids was oxibendazole, fenbendazole, pyrantel pamoate, and ivermectin. Against small strongyles, ivermectin was excellent, but the other compounds virtually were inactive. However, as mentioned earlier, the high activity against small strongyles by ivermectin, indicated by data at 1 to 2 weeks after treatment, may be misleading because EPG counts of these parasites have been returning at about 4 weeks post-treatment. More precise evaluation, such as in critical and controlled tests, needs to be done to verify field test data.
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CAS 20559-55-1 Oxibendazole

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