OXi-4503 sodium - CAS 288847-34-7
Category: APIs
Molecular Formula:
C18H22Na4O12P2
Molecular Weight:
584.23
COA:
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Description:
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. The U.S. Food and Drug Administration (FDA) has granted fast-track designation to OXi-4503, a vascular disrupting agent shown to cause tumor cell death and necrosis, for the treatment of relapsed/refractory acute myeloid leukemia (AML).
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Related CAS:
288847-35-8 (free acid)
Appearance:
Solid powder
Synonyms:
sodium (Z)-3-methoxy-6-(3,4,5-trimethoxystyryl)-1,2-phenylene bis(phosphate); OXi4503; OXi-4503; OXi 4503; OXi-4503 sodium, CA1P; Combretastatin A-1 phosphate.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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InChIKey:
NRKFVEPAQNCYNJ-YGGCHVFLSA-J
InChI:
1S/C18H22O12P2.4Na/c1-25-13-8-7-12(16(29-31(19,20)21)18(13)30-32(22,23)24)6-5-11-9-14(26-2)17(28-4)15(10-11)27-3;;;;/h5-10H,1-4H3,(H2,19,20,21)(H2,22,23,24);;;;/q;4*+1/p-4/b6-5-;;;;
Canonical SMILES:
COC1=C(OC)C(OC)=CC(/C=C\C2=C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)=C(OC)C=C2)=C1.[Na+].[Na+].[Na+].[Na+]
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Chemical Structure

CAS 288847-34-7 OXi-4503 sodium

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