OXi-4503 - CAS 288847-35-8
Catalog number:
B0084-353235
Category:
APIs
Molecular Formula:
C18H22O12P2
Molecular Weight:
492.31
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Description:
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-353235 100 mg $2980 In stock
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
OXi4503; OXi 4503; CA1P; tetrasodium [3-methoxy-2-phosphonatooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
MSDS:
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Current Developer:
OXiGENE
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Chemical Structure

CAS 288847-35-8 OXi-4503

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