Oxfendazole - CAS 53716-50-0
Catalog number: 53716-50-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H13N3O3S
Molecular Weight:
315.35
COA:
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Targets:
Antiparasitic
Description:
Oxfendazole is the sulfoxide form of fenbendazole which is a broad spectrum benzimidazole anthelmintic.
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Purity:
>98%
Synonyms:
RS-8858
MSDS:
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1.Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry.
Klausz G1, Keller É1, Sára Z2, Székely-Körmöczy P3, Laczay P3, Ary K4, Sótonyi P1, Róna K1. Biomed Chromatogr. 2015 Dec;29(12):1859-65. doi: 10.1002/bmc.3507. Epub 2015 Jun 24.
A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method consists of solid-phase extractions on Strata-X polymeric cartridges. Chromatographic separation was carried out on a Phenomenex Gemini C6 -Phenyl column using binary gradient elution containing methanol and 50 mm ammonium-formate (pH 3). The method was linear (r(2)  ≥ 0.990) over concentration ranges of 3-250 ng/mL for PYR andFEB, 5-250 ng/mL for OXF and FEN, and 24-1000 ng/mL for PZQ. The mean precisions were 1.3-10.6% (within-run) and 2.5-9.1% (between-run), and mean accuracies were 90.7-109.4% (within-run) and 91.6-108.2% (between-run). The relative standard deviations (RSD) were <9.1%. The mean recoveries of five targeted compounds from dog plasma ranged from 77 to 94%.
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CAS 53716-50-0 Oxfendazole

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