Oxethazaine - CAS 126-27-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Oxethazaine, an effective topical anesthetic, could be used to relieve the pain caused by peptic ulcer disease and esophagitis.
Publictions citing BOC Sciences Products
  • >> More
White powder.
Chloroform (Slightly), Methanol (Slightly)
-20ºC Freeze
Oxethazaine is an effective topical anesthetic that could be used to relieve the pain caused by peptic ulcer disease and esophagitis.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
1.093 g/cm3
Canonical SMILES:
1.Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.
Huang WH1, Liu CH, Liu RH, Tseng YL. J Anal Toxicol. 2010 Mar;34(2):73-7.
Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medication, oxethazaine. In a recent sporting event, a urine specimen donor who tested positive for mephentermine and phentermine claimed consumption of Mucaine((R)) for treating stomach pain was the reason for testing positive. Five volunteers were administrated oxethazaine (a topical anesthetic found in the multi-ingredient medication Mucaine and its generic equivalent, Stoin, both of which are available in Taiwan), mephentermine, and phentermine. Excretion profiles of mephentermine and phentermine following the administration of these drugs were found to be similar. However, the mephentermine/phentermine ratios found in urine specimens collected at different time points following the administration of oxethazine and mephentermine were found to be characteristically different.
2.Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers.
Masuda Y1, Edo T. J Pharmacol Sci. 2005 Jun;98(2):181-4. Epub 2005 Jun 8.
Clomipramine (CLM) and oxethazaine (OXZ) were previously reported to increase portal pressure by contracting portal vein branches (PVBs) in isolated perfused rat liver. In the present study, to characterize the contractile mechanisms, the effects of Y27632, HA1077, staurosporine, papaverine, SKF96365, and sulindac sulfide on the portal pressure increase induced by CLM and OXZ were examined comparatively with those induced by endothelin-1. The results suggest that 1) intrahepatic PVBs employ a Rho-kinase-dependent pathway for sustained contraction, 2) CLM contracts PVBs by activating a Rho-kinase pathway and Ca(2+)-channels, and 3) OXZ acts primarily by promoting Ca(2+) entry through its ionophore-like action.
3.Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity.
Masuda Y1. J Pharmacol Sci. 2006 Mar;100(3):167-74. Epub 2006 Mar 4.
The liver has an intricate microvascular system that allows homogenous perfusion throughout the organ. However, the regulatory mechanisms of intrahepatic circulation are still unclear, and the effects of drugs on this system have rarely been reported. Oxethazaine, a topical anesthetic, was incidentally found to induce a consistent increase in portal pressure in the isolated perfused rat liver, which led us to characterize this phenomenon. For this, a vital staining method was developed to detect microcirculatory alterations in the isolated liver. Using this method, not only vasoconstrictors like endothelin-1, but the drugs oxethazaine and clomipramine, a tricyclic antidepressant, were found to induce flow redistribution to the deeper and hilar portions of the liver with minimal perfusion at the periphery, which was due to a short-circuit flow at the center owing to the constriction of the intrahepatic portal vein branches. Hepatic nerve stimulation also produced a similar flow disturbance.
4.Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells.
Masuda Y1, Oguma T, Kimura A. Biochem Pharmacol. 2002 Aug 15;64(4):677-87.
There have been few reports on the mechanism(s) of action of oxethazaine (OXZ) despite its potent local anesthetic action. Generally, local anesthetics (LAs) not only inhibit Na(+) channels but also affect various membrane functions. In the present study, using PC12 cells as a nerve cell model, the effects of OXZ on intracellular Ca(2+) concentration ([Ca(2+)](i)) were examined in relation to cytotoxicity and dopamine release. [Ca(2+)](i) was determined by the quin2 method. In resting cells, (6-10)x10(-5)M OXZ produced lactate dehydrogenase leakage, which was Ca(2+)-dependent, inhibited by metal Ca(2+) channel blockers, and preceded by a marked increase in [Ca(2+)](i). Some other LAs showed no cytotoxicity at these concentrations. In K(+)-depolarized cells, however, lower concentrations of OXZ (10(-6)-10(-7)M), that had no effect on resting [Ca(2+)](i), inhibited both the dopamine release and the increase of [Ca(2+)](i) in parallel. The inhibitory potency against the [Ca(2+)](i) increase was in the order of nifedipine>OXZ approximately verapamil>diltiazem, and OXZ acted additively on the Ca(2+) channel blockers.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 1448189-80-7 Protein degrader 1 hydrochloride

Protein degrader 1 hydrochloride
(CAS: 1448189-80-7)

Protein degrader 1, also called as MDK7526, is used in the synthesis of HaloPROTACs and a potent and selective protein degrader.

CAS 1955550-51-2 FMK 9a

FMK 9a
(CAS: 1955550-51-2)

FMK 9a is a covalent autophagin-1 inhibitor (IC50= 80 and 73 μM in FRET and LRA assay).

CAS 341-69-5 Orphenadrine hydrochloride

Orphenadrine hydrochloride
(CAS: 341-69-5)

A skeletal muscle relaxant used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

Gyki 13324
(CAS: 76123-41-6)

GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. It can produce long-term or total regression of adenomatous, but only marginal growth ...

CAS 13739-02-1 Diacerein

(CAS: 13739-02-1)

Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.

CAS 37921-38-3 Cimifugin

(CAS: 37921-38-3)

Cimifugin is a major components of Yu-ping-feng-san, a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing aller...

CAS 142873-41-4 Lipid peroxidation inhibitor 1

Lipid peroxidation inhibitor 1
(CAS: 142873-41-4)

A lipid peroxidation inhibitor (IC50= 0.07 μM).

CAS 147493-44-5 Pyridazinediones-derivative-1

(CAS: 147493-44-5)

It inhibits glutamate-induced contractions of isolated guineapig ileum (ED50= 2.1 μM) with potential to treat neurodegenerative disorders.

(CAS: 1628317-18-9)

MI-463, a thienopyrimidine derivative, has been found to be a menin inhibitor that could be significant in Leukaemia studies.

CAS 2179-37-5 Benzcyclane

(CAS: 2179-37-5)

Benzcyclane, also called as Bencyclane or Benzcyclan, is a platelet aggregation inhibitor and used as a vasodilator effective.

CAS 173424-77-6 Cloretazine

(CAS: 173424-77-6)

Cloretazine, a sulfonyl hydrazine derivative, has been found to exhibit antineoplastic activity through influencing DNA repairment.

CAS 6078-17-7 Berbamine Hydrochloride

Berbamine Hydrochloride
(CAS: 6078-17-7)

Berbamine hydrochloride, a natural compound derived from the Berberis amurensis plant, might affect the transport of intracellular Ca(2+).

(CAS: 332178-44-6)

CP-671906-01 is a neuropeptide Y1 receptor antagonists, increasing blood pressure and food intake in rat models.

CAS 120-51-4 Benzyl Benzoate

Benzyl Benzoate
(CAS: 120-51-4)

Benzyl benzoate, extracted from Cinnamomum zeylanicum leaves and stem bark, could be used as a pediculicide.

CAS 114084-78-5 Ibandronic acid

Ibandronic acid
(CAS: 114084-78-5)

Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

(CAS: 1243244-74-7)

This active molecular is a selective Porcupine protein inhibitor and IC50 value is 0.8nM. GNF-6231 shows efficient pathway inhibition and induced robust antitum...

CAS 134418-28-3 Dehydroandrographolide

(CAS: 134418-28-3)

Dehydroandrographolide is a natural diterpenoid found in Andrographis paniculata. It possesses activity against hepatitis B virus DNA replication.

CAS 86170-12-9 CGP 23996

CGP 23996
(CAS: 86170-12-9)

CGP 23996 is a non-reducible somatostatin analog. It can be used for autoradiography.

CAS 1801747-42-1 SHP099

(CAS: 1801747-42-1)

SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation....

CAS 10040-45-6 Sodium Picosulfate

Sodium Picosulfate
(CAS: 10040-45-6)

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.Sodium Picosulphate treatment for long-term has no effects on ne...

Chemical Structure

CAS 126-27-2 Oxethazaine

Quick Inquiry

Verification code

Featured Items