Oxcarbazepine - CAS 28721-07-5
Catalog number:
28721-07-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H12N2O2
Molecular Weight:
252.27
COA:
Inquire
Targets:
Sodium Channel
Description:
Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine is marketed as Trileptal by Novartis and available in some countries as a generic drug.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
GP47680
MSDS:
Inquire
1.Efficacy and acceptability of oxcarbazepine vs. carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia: a retrospective review.
Yi C1, Wenping X1, Hui X1, Xin H1, Xiue L1, Jun Z1, Shangyong G1. Postgrad Med. 2016 Apr 8. [Epub ahead of print]
OBJECTIVES: Vestibular paroxysmia (VP) is a rare episodic peripheral vestibular disorder that can cause acute short attacks of vertigo. This study aimed to compare the efficacy and acceptability of carbamazepine (CBZ), CBZ plus betahistine mesilate tablets (BMT) and oxcarbazepine (OXC) plus BMT in treating VP within 12 weeks.
2.The Curse of the Dolphins: Cognitive Decline and Psychosis.
Phelps R1, Tsai A, Hagen A, Pinter J, Smith R, Stein MT. J Dev Behav Pediatr. 2016 Apr 18. [Epub ahead of print]
CASE: Isela is an 11-year-old Mexican-American girl with mild intellectual disability. During a vacation with her family, she went swimming with dolphins. A few days later, Isela awoke at night with laughing spells; during the day, she was pacing, aggressive, and had a decline in self-care and communication skills. Her parents attributed the symptoms to the dolphins. She was evaluated by a pediatric neurologist. The sleep-deprived electroencephalogram, brain magnetic resonance imaging, lumbar puncture, and thyroid function tests were normal. A genomic microarray was sent. The neurologist initiated empirical therapy for seizures with lamotrigine, which caused a rash. It was discontinued. She was then treated with oxcarbazepine followed by topiramate for several months without any change in symptoms. Comparative genomic hybridization revealed a small deletion at 14q13.1, which includes the NPAS3 gene. Psychiatry was consulted after several months of persistent symptoms.
3.Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma.
Yang Z1, Xu X1, Sun L1, Zhao X1, Wang H1, Fawcett JP2, Yang Y3, Gu J4. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:36-42. doi: 10.1016/j.jchromb.2016.03.013. Epub 2016 Mar 15.
A rapid and sensitive assay based on supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS) has been developed and validated for the determination of oxcarbazepine (OXC) and its chiral metabolite licarbazine (Lic) in beagle dog plasma using carbamazepine as internal standard. Chiral analysis in a run time of only 3min was performed on an ACQUITY UPC(2) ™ Trefoil™ CEL2 column (3.0×150mm, 2.5μm) at 50°C by isocratic elution with a mobile phase of supercritical carbon dioxide (purity≥99.99%) and methanol (60:40, v/v) at a flow rate of 2.3mL/min. The assay was linear over the concentration ranges 5-1000ng/mL for OXC and 0.5-100ng/mL for the enantiomers of Lic with corresponding lower limits of quantitation of 5ng/mL and 0.5ng/mL. Intra- and inter-day precisions were in the range 0.78-14.14% with accuracies in the range -10.80% to 0.42%. The method was successfully applied to a pharmacokinetic study involving a single oral administration of 16mg/kg OXC as Trileptal(@) tablets to beagle dogs.
4.Pain phenotype as a predictor for drug response in painful polyneuropathy A retrospective analysis of data from controlled clinical trials.
Holbech JV1, Bach FW, Finnerup NB, Jensen TS, Sindrup SH. Pain. 2016 Mar 22. [Epub ahead of print]
The drugs available for treatment of neuropathic pain have a somewhat disappointing efficacy with many patients left with limited or no effect. Individualized treatment based on phenotype according to presumed underlying pain mechanism(s) has been proposed to improve outcome. We report a retrospective analysis of phenotype-specific effects of several neuropathic pain drugs, which were studied in a series of cross-over, placebo-controlled, clinical trials. The data originate from 7 trials with similar design and outcome recordings, which all had a thorough baseline registration of symptoms, signs and quantitative sensory testing. The latter was used to phenotype patients into subgroups reflecting presumed pain mechanisms. There were a total of 361 patient records distributed over treatments with 4 antidepressants and 4 anticonvulsants. Five of the drugs reduced total pain significantly compared to placebo. Only a few phenotype-specific differences in total pain reduction were found within the investigated drugs.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 57-41-0 Phenytoin

Phenytoin
(CAS: 57-41-0)

Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage gated sodium channels.

CAS 1744-22-5 Riluzole

Riluzole
(CAS: 1744-22-5)

Riluzole is a drug used to treat amyotrophic lateral sclerosis.

CAS 630-93-3 Phenytoin Sodium

Phenytoin Sodium
(CAS: 630-93-3)

Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.

PF-05089771
(CAS: 1235403-62-9)

PF-05089771, a Nav1.7 channel blocker, has been studied to have potential effect in the treatment of chronic neuropathic pain. It is still under Phase II clinic...

PF-05241328
(CAS: 1387633-03-5)

PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50= 31nM) for the treatment of pain. But P...

CAS 74517-78-5 Indecainide

Indecainide
(CAS: 74517-78-5)

Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued.

CAS 944261-79-4 A-803467

A-803467
(CAS: 944261-79-4)

A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).

CAS 95635-55-5 Ranolazine

Ranolazine
(CAS: 95635-55-5)

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

T-1095
(CAS: 209746-59-8)

T-1095, with potential antidiabetic effect, is an inhibitor of renal Na+-glucose cotransporters that may provide a novel way to treating diabetes.

Nav1.7 inhibitor
(CAS: 1355631-24-1)

Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia.

CAS 42971-09-5 Vinpocetine

Vinpocetine
(CAS: 42971-09-5)

Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.

CAS 66794-74-9 Encainide Hydrochloride

Encainide Hydrochloride
(CAS: 66794-74-9)

Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated so...

Eleclazine
(CAS: 1443211-72-0)

Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and en...

CAS 159138-80-4 Cariporide

Cariporide
(CAS: 159138-80-4)

Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity fo...

CAS 298-46-4 Carbamazepine

Carbamazepine
(CAS: 298-46-4)

Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegr...

CAS 1234365-97-9 Tenapanor HCl

Tenapanor HCl
(CAS: 1234365-97-9)

Tenapanor, also known as AZD-1722 and RDX 5791, is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. Tenapanor ...

Sodium Channel inhibitor 1
(CAS: 1198117-23-5)

Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatm...

CAS 86-35-1 ETHOTOIN

ETHOTOIN
(CAS: 86-35-1)

Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoi...

PF-04856264
(CAS: 1235397-05-3)

This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...

CAS 166196-11-8 CGP-47292

CGP-47292
(CAS: 166196-11-8)

CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.

Chemical Structure

CAS 28721-07-5 Oxcarbazepine

Quick Inquiry

Verification code

Featured Items