Oxadiazon - CAS 19666-30-9
Catalog number: 19666-30-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Oxadiazon is a widely used herbicide that is selective for the control of grasses and annual weeds.
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Crystalline solid
5-tert-butyl-3-(2,4-dichloro-5-propan-2-yloxyphenyl)-1,3,4-oxadiazol-2-one 2-(tert-butyl)-4-(2,4-dichloro-5-isopropyloxy-phenyl) delta(2)-1,3,4-oxadiazoline-5-one oxadiazon Ronstar
Soluble in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -27℃ for long term (months to years).
Shelf Life:
2 years
Boiling Point:
417.0±55.0 °C | Condition: Press: 760 Torr
Melting Point:
90 °C
1.31 g/cm3
Canonical SMILES:
1.Predicting the aquatic risk of realistic pesticide mixtures to species assemblages in Portuguese river basins.
Silva E1, Daam MA2, Cerejeira MJ2. J Environ Sci (China). 2015 May 1;31:12-20. doi: 10.1016/j.jes.2014.11.006. Epub 2015 Mar 11.
Although pesticide regulatory tools are mainly based on individual substances, aquatic ecosystems are usually exposed to multiple pesticides from their use on the variety of crops within the catchment of a river. This study estimated the impact of measured pesticide mixtures in surface waters from 2002 and 2008 within three important Portuguese river basins ('Mondego', 'Sado' and 'Tejo') on primary producers, arthropods and fish by toxic pressure calculation. Species sensitivity distributions (SSDs), in combination with mixture toxicity models, were applied. Considering the differences in the responses of the taxonomic groups as well as in the pesticide exposures that these organisms experience, variable acute multi-substance potentially affected fractions (msPAFs) were obtained. The median msPAF for primary producers and arthropods in surface waters of all river basins exceeded 5%, the cut-off value used in the prospective SSD approach for deriving individual environmental quality standards.
2.Constitutive active/androstane receptor, peroxisome proliferator-activated receptor α, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.
Kuwata K1, Inoue K2, Ichimura R2, Takahashi M2, Kodama Y3, Yoshida M4. Food Chem Toxicol. 2016 Feb;88:75-86. doi: 10.1016/j.fct.2015.12.017. Epub 2015 Dec 19.
Oxadiazon (OX) is a protoporphyrinogen oxidase-inhibiting herbicide that induces porphyria and liver tumors in rodents. Although porphyria is generally considered to be a risk factor for liver tumor development, the mechanisms through which OX mediates tumor development are unclear. Therefore, in this study, we investigated the mechanisms of tumor development by focusing on constitutive active/androstane receptor (CAR), which is essential for the development of tumors in response to several chemicals. After 1, 4, or 13 weeks of dietary treatment with 1000 ppm OX, hepatic Cyp2b10 expression was induced in wild-type (WT) mice. However, this effect was blocked in CAR-knockout (CARKO) mice. Hepatic Cyp4a10 expression, indicative of peroxisome proliferator-activated receptor α (PPARα) activation, and cytotoxic changes in hepatocytes were also observed in both groups of mice. After initiation by diethylnitrosamine, 26-week treatment with OX resulted in an increase in proliferative lesions, including foci and adenomas, in both genotypes, and the incidence and multiplicity of proliferative lesions in CARKO mice were higher than those in control mice but lower than those in WT mice.
3.Use of semipermeable membrane devices for monitoring pesticides in indoor air.
Esteve-Turrillas FA1, Pastor A, De La Guardia M. J AOAC Int. 2009 Sep-Oct;92(5):1557-65.
In this work, 40 pesticides from different categories were analyzed in the air of 20 indoor places that have an intensive use of pesticides. Passive sampling was carried out by using semipermeable membrane devices (SPMDs) deployed for 7 days. SPMDs were analyzed using microwave-assisted extraction and GC/MS. PCB-195 was used as an internal standard. Recoveries ranged between 81 and 108% for many compounds, with RSD values < 11%. Typical LOD values for 7 days of sampling were from 0.1 to 3.1 ng/m. Propamocarb, propoxur, carbosulfan, pirimicarb, metribuzin, metalaxyl, pendimethalin, oxadiazon, phenothrin, and permethrin were detected in 11 sampling sites, with air concentrations in the range from 1 to 921 ng/m. However, the pesticide levels found cannot be considered a serious health problem according to results from other pesticide monitoring studies.
4.Occurrence and removal of organic micropollutants: An overview of the watch list of EU Decision 2015/495.
Barbosa MO1, Moreira NF1, Ribeiro AR1, Pereira MF1, Silva AM2. Water Res. 2016 May 1;94:257-79. doi: 10.1016/j.watres.2016.02.047. Epub 2016 Feb 23.
Although there are no legal discharge limits for micropollutants into the environment, some regulations have been published in the last few years. Recently, a watch list of substances for European Union-wide monitoring was reported in the Decision 2015/495/EU of 20 March 2015. Besides the substances previously recommended to be included by the Directive 39/2013/EU, namely two pharmaceuticals (diclofenac and the synthetic hormone 17-alpha-ethinylestradiol (EE2)) and a natural hormone (17-beta-estradiol (E2)), the first watch list of 10 substances/groups of substances also refers three macrolide antibiotics (azithromycin, clarithromycin and erythromycin), other natural hormone (estrone (E1)), some pesticides (methiocarb, oxadiazon, imidacloprid, thiacloprid, thiamethoxam, clothianidin, acetamiprid and triallate), a UV filter (2-ethylhexyl-4-methoxycinnamate) and an antioxidant (2,6-di-tert-butyl-4-methylphenol) commonly used as food additive.
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CAS 19666-30-9 Oxadiazon

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