Oxacillin sodium salt - CAS 1173-88-2
Catalog number: 1173-88-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H18N3NaO5S
Molecular Weight:
423.42
COA:
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Targets:
Antibacterial
Description:
The sodium salt form of Oxacillin which is a narrow-spectrum antibiotic and commonly used for studying the mechanisms of penicillinase resistance.
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Purity:
95%
Appearance:
Crystalline
Synonyms:
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(5-methyl-3;5-methyl-3-phenyl-4-isoxazolylpenicillin,sodium;bactocill;bristopen;brl1400;cryptocillin;micropenin;monosodiumoxacillin
Solubility:
H2O: 88 mg/mL, DMSO: < 1 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The sodium salt form of Oxacillin which is a narrow-spectrum antibiotic and commonly used for studying the mechanisms of penicillinase resistance.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Density:
1.49g/cm3
InChIKey:
VDUVBBMAXXHEQP-SLINCCQESA-M
InChI:
InChI=1S/C19H19N3O5S.Na/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);/q;+1/p-1/t13-,14+,17-;/m1./s1
Canonical SMILES:
CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
1.High prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene in a semi-extensive red deer (Cervus elaphus hispanicus) farm in Southern Spain.
Gómez P1, Lozano C1, González-Barrio D2, Zarazaga M1, Ruiz-Fons F2, Torres C3. Vet Microbiol. 2015 Jun 12;177(3-4):326-31. doi: 10.1016/j.vetmic.2015.03.029. Epub 2015 Apr 14.
The objective was to determine the prevalence of Staphylococcus aureus nasal carriage in red deer of a semi-extensive farm and in humans in contact with the estate animals, and to characterize obtained isolates. Nasal swabs of 65 deer and 15 humans were seeded on mannitol-salt-agar and oxacillin-resistance-screening-agar-base. Isolates were identified by microbiological and molecular methods. Antimicrobial susceptibility profile was determined for 16 antibiotics by disk-diffusion and the presence of eight antibiotic resistance genes, seven virulence genes and genes of immune-evasion-cluster (IEC) was analyzed by PCR. S. aureus was typed by PFGE-SmaI, spa, agr, SCCmec and MLST. Isolates were detected in 16 deer (24.6%). Eleven S. aureus isolates were methicillin-resistant (MRSA), and five were methicillin-susceptible (MSSA). All MRSA harbored mecC gene and were agr-III/SCCmecXI/ST1945 (four spa-t843 and seven spa-t1535). All mecC-MRSA carried blaZ-SCCmecXI and etd2, were IEC-type-E, and belonged to the same PFGE pattern.
2.Extravasation of Noncytotoxic Drugs: A Review of the Literature.
Le A1, Patel S2. Ann Pharmacother. 2014 Apr 8;48(7):870-886. [Epub ahead of print]
OBJECTIVE: Extravasation is a potential complication associated with intravenous therapy administration. Inadvertent leakage of medications with vesicant properties can cause severe tissue necrosis, which can lead to devastating long-term consequences. Recognizing potential agents is an essential step in mitigating the risk of extravasation.
3.Comparative study of the effect of pharmaceutical additives on the elimination of antibiotic activity during the treatment of oxacillin in water by the photo-Fenton, TiO2-photocatalysis and electroc
Serna-Galvis EA1, Silva-Agredo J1, Giraldo AL2, Flórez-Acosta OA2, Torres-Palma RA3. Sci Total Environ. 2016 Jan 15;541:1431-8. doi: 10.1016/j.scitotenv.2015.10.029. Epub 2015 Nov 11.
Synthetic pharmaceutical effluents loaded with the β-lactam antibiotic oxacillin were treated using advanced oxidation processes (the photo-Fenton system and TiO2 photocatalysis) and chloride mediated electrochemical oxidation (with Ti/IrO2 anodes). Combinations of the antibiotic with excipients (mannitol or tartaric acid), an active ingredient (calcium carbonate, i.e. bicarbonate ions due to the pH) and a cleaning agent (sodium lauryl ether sulfate) were considered. Additionally, urban wastewater that had undergone biological treatment was doped with oxacillin and treated with the tested systems. The evolution of antimicrobial activity was monitored as a parameter of processes efficiency. Although the two advanced oxidation processes (AOPs) differ only in the way they produce OH, marked differences were observed between them. There were also differences between the AOPs and the electrochemical system. Interestingly, each additive had a different effect on each treatment.
4.Laboratory evaluation of phenotypic detection methods of methicillin-resistant Staphylococcus aureus.
Kali A1, Stephen S, Umadevi S. Biomed J. 2014 Nov-Dec;37(6):411-4. doi: 10.4103/2319-4170.132907.
Although conventional antibiotic susceptibility tests are most commonly performed for methicillin-resistant Staphylococcus aureus (MRSA), the results of these phenotypic tests are dependent on the standardization of the culture conditions. The aim of the study was to evaluate the conventional phenotypic screening tests in comparison to the mecA gene polymerase chain reaction (PCR). One hundred and two clinical isolates of MRSA identified by the oxacillin disk diffusion were subjected to PCR for the mecA gene and by the cefoxitin disk diffusion test and culture on oxacillin screen agar, mannitol salt agar, and methicillin-resistant Staphylococcus aureus Agar (MeReSA) selective medium, for MRSA. Although all 102 isolates were resistant in oxacillin and cefoxitin disk diffusion, 92 (90.1%) isolates were positive for the mecA gene. The sensitivities of the mannitol salt agar, MeReSA agar, and oxacillin screen agar were 89.13, 97.82, and 98.91%, respectively.
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CAS 1173-88-2 Oxacillin sodium salt

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