Oxacillin - CAS 66-79-5
Catalog number: 66-79-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H19N3O5S
Molecular Weight:
401.44
COA:
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Description:
Oxacillin is a semisynthetic penicillinase-resistant and acid-stable penicillin with an antimicrobial activity. It is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is widely used in resistant staphylococci infections. It binds to penicillin-binding proteins in the bacterial cell wall, thus blocking the synthesis of peptidoglycan, which leads to inhibition of cell growth and causes cell lysis. It was developed by Beecham and has been listed.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
[2S-(2,5,6)]-3,3-dimethyl-6-(methyl-3-phenylisoxaz-4-ole-carboxamide-7-oxy-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2S,5R,6R)-3,3-Dimethyl-6-[(5-methyl-3-phenylisoxazol-4-yl)carbonylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic a
Solubility:
27.8 mg/L at 25 ℃
Storage:
-20°C Freezer
MSDS:
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Application:
Oxacillin is widely used in resistant staphylococci infections.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
686.8±55.0 °C | Condition: Press: 760 Torr
Melting Point:
188 °C
Density:
1.49±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
UWYHMGVUTGAWSP-JKIFEVAISA-N
InChI:
InChI=1S/C19H19N3O5S/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26)/t13-,14+,17-/m1/s1
Canonical SMILES:
CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Current Developer:
Oxacillin was developed by Beecham and has been listed.
1.Retropubic Midurethral Sling Colonization With Staphylococcus lugdunensis.
Stone DE1, Swarer KM, Barenberg BJ, OʼLeary DE. Female Pelvic Med Reconstr Surg. 2016 Apr 6. [Epub ahead of print]
BACKGROUND: We present a case of Staphylococcus lugdunensis colonization of a midurethral sling. Staphylococcus lugdunensis is a common skin colonizer and has been isolated in cases of implanted prosthetic devices.
2.Hospital air: A potential route for transmission of infections caused by β-lactam-resistant bacteria.
Mirhoseini SH1, Nikaeen M2, Shamsizadeh Z3, Khanahmad H4. Am J Infect Control. 2016 Mar 24. pii: S0196-6553(16)00147-4. doi: 10.1016/j.ajic.2016.01.041. [Epub ahead of print]
BACKGROUND: The emergence of bacterial resistance to β-lactam antibiotics seriously challenges the treatment of various nosocomial infections. This study was designed to investigate the presence of β-lactam-resistant bacteria (BLRB) in hospital air.
3.Genotyping and serotyping of macrolide and multidrug resistant Streptococcus pneumoniae isolated from carrier children.
Swedan SF1, Hayajneh WA, Bshara GN. Indian J Med Microbiol. 2016 Apr-Jun;34(2):159-65. doi: 10.4103/0255-0857.176840.
AIMS: Streptococcus pneumoniae, an opportunistic pathogen commonly carried asymptomatically in the nasopharynx of children, is associated with increasing rates of treatment failures due to a worldwide increase in drug resistance. We investigated the carriage of S. pneumoniae in children 5 years or younger, the identity of prevalent serotypes, the rates of resistance to macrolides and other antimicrobial agents and the genotypes responsible for macrolide resistance.
4.Methicillin-resistant Staphylococcus aureus with mecC: a description of 45 human cases in southern Sweden.
Lindgren AK1,2, Gustafsson E3, Petersson AC4, Melander E5. Eur J Clin Microbiol Infect Dis. 2016 Mar 24. [Epub ahead of print]
In 2011, a novel mecA gene homologue, mecC, was reported in isolates from both humans and dairy cattle. The epidemiology of mecC methicillin-resistant Staphylococcus aureus (MRSA) in humans is not yet well known. In this retrospective study, we present the epidemiology of human clinical cases with mecC MRSA detected in the southern part of Sweden during the period 2005-2014. A total of 45 patients with an isolate positive for mecC MRSA were included in the study. Twenty-six isolates were found before 2012 and were retrospectively tested for mecC. Nineteen isolates were detected in 2012-2014 through routine testing. Culture results, resistance patterns, Panton-Valentine leukocidin (PVL) genes, and spa types were collected from the Clinical Microbiology Laboratory. Epidemiological data were received from the database at the Regional Centre for Communicable Disease Control and the patient's medical files. The majority of the patients with mecC MRSA were of Swedish origin, had underlying diseases, and lived in rural areas.
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CAS 66-79-5 Oxacillin

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