Oxaceprol - CAS 33996-33-7
Catalog number: 33996-33-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Oxaceprol derived from L-proline, inhibiting inflammatory cell infiltration and bone damage in the adjuvant-injected paw.
Publictions citing BOC Sciences Products
  • >> More
White powder
trans-1-Acetyl-4-hydroxy-L-proline; N-Acetyl-L-hydroxyproline;
Soluble in DMSO
Store at RT.
An anti-inflammatory drug used in the treatment of osteoarthritis.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
442.1ºC at 760 mmHg
Melting Point:
132-133ºC (dec.)
1.439 g/cm3
Canonical SMILES:
1.[Autoradiography studies of the effect of oxaceprol on the metabolism of joint cartilage in vitro and in vivo].
Kalbhen DA, Kalkert B. Z Rheumatol. 1987 May-Jun;46(3):136-42.
Using the radiolabelled precursors (3H-Glucosamine, 3H-proline) and a new procedure of quantitative microautoradiography we investigated the influence of N-acetyl-L-hydroxyproline (Oxaceprol) on anabolic processes in joint cartilage tissue of hens. After in vitro incubation, Oxaceprol stimulated the uptake of 3H-glucosamine and 3H-proline in chondrocytes and enhanced the incorporation of 3H-proline into the macromolecular structures of the cartilage matrix. Also, after in vivo intra-articular injection of Oxaceprol into the knee joints we could demonstrate a significant increase of intracellular glucosamine uptake. Because in our micro-autoradiographic detection method low molecular substances are excluded, the higher rate of precursor incorporation into cells and matrix can be interpreted as a stimulation of proteoglycan and collagen synthesis.
2.Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis.
Veihelmann A1, Hofbauer A, Refior HJ, Messmer K. Acta Orthop Scand. 2001 Jun;72(3):293-8.
Oxaceprol (N-acetyl-L-hydroxyproline), an atypical inhibitor of inflammation, is an established drug forjoint disease without serious side-effects. Recent studies have emphasized that oxaceprol has an effect on the microcirculation. Since the exact mechanism of action remains unclear, the aim of our study was to investigate the leukocyte-endothelial cell interactions in oxaceprol-treated mice with antigen-induced arthritis (AiA) using intravital microscopy. In our study, Balb/c mice were allocated to 4 groups (n 7, 8, 8, 8): 2 control groups with saline or oxaceprol and 2 groups of arthritic animals which received saline or oxaceprol (100 mg/kg twice a day intraperitoneally). The severity of arthritis was quantified by the transverse knee joint diameter. For the intravital fluorescence microscopy measurements on day 10 after inducing arthritis, the patella tendon was partily resected to visualize the intraarticular synovial tissue of the knee joint.
3.Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus.
Hashizume E1, Nakano T, Kamimura A, Morishita K. Clin Cosmet Investig Dermatol. 2013;6:43-9. doi: 10.2147/CCID.S39370. Epub 2013 Feb 12.
PURPOSE: N-acetyl-l-hydroxyproline (AHYP) is an acetylated form of l-hydroxyproline that is used to treat skin ulcers and porphyria cutanea tarda. Its other biological and physiological effects on the skin have not been elucidated. We investigated the effects of AHYP on the skin-barrier function, focusing on ceramide synthesis and the effects of topical AHYP on atopic dermatitis.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 13309-08-5 3PO

(CAS: 13309-08-5)

3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM), with the potential to inhibit cancer cell proliferation. The addition of selective inhibitors of au...

CAS 1384071-99-1 AD80

(CAS: 1384071-99-1)

AD80, also called as A-196, is a multikinase inhibitor that inhibits against human BRAF, S6K, and SRC and shows strong activity against RET inhibitor.

CAS 58-15-1 Amidopyrine

(CAS: 58-15-1)

Aminophenazone (or aminopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis.

CI 924
(CAS: 79520-77-7)

CI 924 is hypolipidemic agent. It can elevate anti-atherogenic HDL and lower VLDL.

CAS 17008-69-4 Pseudobufarenogin

(CAS: 17008-69-4)

Pseudobufarenogin is a natural compound extracted from toad species with unknown details.

(CAS: 309959-34-0)

ABT-202, a small molecule, asts as an agonist at neural nicotinic acetylcholine receptors.

CAS 121268-17-5 Alendronate sodium hydrate

Alendronate sodium hydrate
(CAS: 121268-17-5)

Alendronate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.

CAS 606-68-8 NADH (disodium salt)

NADH (disodium salt)
(CAS: 606-68-8)

NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.

CAS 555-77-1 Trichlormethine

(CAS: 555-77-1)

Trichloromethane is a solvent, as a powerful blister agent used for chemical warfare.

KHK-IN-1 hydrochloride
(CAS: 1303470-48-5)

The hydrochloride salt form of KHK-IN-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in...

CAS 158353-15-2 Pyraclonil

(CAS: 158353-15-2)

Pyraclonil is a herbicide agent.

CAS 15411-54-8 Terephthalamidine

(CAS: 15411-54-8)

Terephthalamidine, a phthalanilide derivative, could bind to DNA double helix selectively.

Evogliptin hydrochloride
(CAS: 1246960-27-9)

CAS 57-08-9 6-Acetamidohexanoic acid

6-Acetamidohexanoic acid
(CAS: 57-08-9)

6-Acetamidohexanoic acid is used in inhibiting the Gastrointestinal disease like gastric ulcer or small bowel inflammation. It is often used after some oral adm...

CAS 60-70-8 Veratramine

(CAS: 60-70-8)

Veratramine is useful as a signal transduction inhibitor for treating tumors.

CAS 3486-66-6 Coptisine

(CAS: 3486-66-6)

Coptisine is an alkaloid extract from the herbs of Chelidonium majus L, has been found to reversibly inhibit Monoamine oxidase A in mice.

CAS 518-69-4 Corydaline

(CAS: 518-69-4)

Corydaline, extracted from Corydalis ambigua, is one of the major active constituents in a new prokinetic botanical agent exhibiting the antiacetylcholinesteras...

CAS 148-79-8 Thiabendazole

(CAS: 148-79-8)

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

CAS 80306-38-3 AR-7

(CAS: 80306-38-3)

AR-7, also known as Atypical retinoid 7, was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing ...

CAS 131064-74-9 CGP-42454A

(CAS: 131064-74-9)

CGP-42454A is a epimer of Benazepril ,an approved drug using for the treatment of Hypertension.

Chemical Structure

CAS 33996-33-7 Oxaceprol

Quick Inquiry

Verification code

Featured Items