|Description||OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells.|
|Synonyms||1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone; OTSSP167 free base; OTSSP 167; OTSSP-167; OTS167; OTS-167; OTS 167|
The hydrochloride salt form of MELK-T1, is a benzoazepin derivative, has been found to be a MELK inhibitor that could induce the degradation of MELK protein and...
OTSSP167 (Hydrochloride) is the hydrochloride salt form of OTSSP167. OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which reg...
MELK-T1, is a benzoazepin derivative, has been found to be a MELK inhibitor that could induce the degradation of MELK protein and deduce the DNA-damage toleranc...
OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upo...