Osthole - CAS 484-12-8
Catalog number: B0084-188779
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H16O3
Molecular Weight:
244.29
COA:
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Targets:
Calcium Channel
Description:
Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also regulates the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK.
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Catalog Number Size Price Stock Quantity
B0084-188779 250 g $488 In stock
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Brife Description:
calcium channel modulator
Purity:
≥ 98%
Synonyms:
Osthol; 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
MSDS:
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InChIKey:
MBRLOUHOWLUMFF-UHFFFAOYSA-N
InChI:
InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
Canonical SMILES:
CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
1.Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
Hao Y1, Liu Y. Biol Pharm Bull. 2016 Apr 1;39(4):457-65. doi: 10.1248/bpb.b15-00358. Epub 2016 Jan 28.
Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there are few promising methods for treating PF, and they are invariably accompanied by severe side effects. Recent studies have showed that the traditional Chinese herbal extract, osthole, had beneficial effects on lipopolysaccharide (LPS) induced acute lung injury (ALI) via an ACE2 pathway. Here we further investigated the protective effects of osthole on bleomycin induced pulmonary fibrosis and attempted to determine the underlying mechanism. PF mode rats were induced by bleomycin (BLM) and then subsequently administered osthole. Histopathological analyses were employed to identify PF changes. The results showed that BLM resulted in severe PF and diffuse lung inflammation, together with significant elevation of inflammatory factors and a marked increase in expression of angiotensin II (ANG II) and transforming growth factor-beta 1 (TGF-β1).
2.Anti-Leishmania Activity of Osthole.
Kermani EK1, Sajjadi SE1, Hejazi SH2, Arjmand R3, Saberi S2, Eskandarian AA2. Pharmacognosy Res. 2016 Mar;8(Suppl 1):S1-4. doi: 10.4103/0974-8490.178650.
BACKGROUND: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens.
3.Neuroprotection of Osthole against Cerebral Ischemia/Reperfusion Injury through an Anti-apoptotic Pathway in Rats.
Li K1, Ding D, Zhang M. Biol Pharm Bull. 2016;39(3):336-42. doi: 10.1248/bpb.b15-00699.
Cerebral ischemia/reperfusion (I/R) injury is a major cause of acute brain injury. The pathogenetic mechanisms underlying I/R injury involve apoptosis, inflammation and oxidative stress. Osthole-a plant coumarin compound-has been reported to protect against focal cerebral I/R-induced injury in rats. However, the mechanism remains unknown. Here we hypothesize that osthole acts through inhibition of apoptosis during focal cerebral I/R injury in rats. We induced cerebral I/R injury by middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. We randomly assigned 60 rats to three groups (20 rats per group): sham-operated, vehicle-treated I/R, and osthole-treated I/R. We treated rats intraperitoneally with osthole (40 mg/kg) or vehicle 30 min before cerebral ischemia. We harvested the brains for infarct volume, brain water content, histological changes and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining as well as cleaved caspase-3, bax, and bcl-2 levels 24 h after reperfusion.
4.[Inhibition of osthole for resorption of rats femur tissue in vitro].
Zhou J, Ren XM, Ma XN, Gao YH, Yan LJ, Shi WG, Chen KM. Zhongguo Gu Shang. 2015 Sep;28(9):832-7.
OBJECTIVE: To investigate osthole effect on femoral tissue resorption activity of rat in vitro.
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CAS 484-12-8 Osthole

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