Osthole - CAS 484-12-8
Catalog number: B0084-188779
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Calcium Channel
Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also regulates the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-188779 250 g $488 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
calcium channel modulator
≥ 98%
Osthol; 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
Canonical SMILES:
1.Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
Hao Y1, Liu Y. Biol Pharm Bull. 2016 Apr 1;39(4):457-65. doi: 10.1248/bpb.b15-00358. Epub 2016 Jan 28.
Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there are few promising methods for treating PF, and they are invariably accompanied by severe side effects. Recent studies have showed that the traditional Chinese herbal extract, osthole, had beneficial effects on lipopolysaccharide (LPS) induced acute lung injury (ALI) via an ACE2 pathway. Here we further investigated the protective effects of osthole on bleomycin induced pulmonary fibrosis and attempted to determine the underlying mechanism. PF mode rats were induced by bleomycin (BLM) and then subsequently administered osthole. Histopathological analyses were employed to identify PF changes. The results showed that BLM resulted in severe PF and diffuse lung inflammation, together with significant elevation of inflammatory factors and a marked increase in expression of angiotensin II (ANG II) and transforming growth factor-beta 1 (TGF-β1).
2.Anti-Leishmania Activity of Osthole.
Kermani EK1, Sajjadi SE1, Hejazi SH2, Arjmand R3, Saberi S2, Eskandarian AA2. Pharmacognosy Res. 2016 Mar;8(Suppl 1):S1-4. doi: 10.4103/0974-8490.178650.
BACKGROUND: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens.
3.Neuroprotection of Osthole against Cerebral Ischemia/Reperfusion Injury through an Anti-apoptotic Pathway in Rats.
Li K1, Ding D, Zhang M. Biol Pharm Bull. 2016;39(3):336-42. doi: 10.1248/bpb.b15-00699.
Cerebral ischemia/reperfusion (I/R) injury is a major cause of acute brain injury. The pathogenetic mechanisms underlying I/R injury involve apoptosis, inflammation and oxidative stress. Osthole-a plant coumarin compound-has been reported to protect against focal cerebral I/R-induced injury in rats. However, the mechanism remains unknown. Here we hypothesize that osthole acts through inhibition of apoptosis during focal cerebral I/R injury in rats. We induced cerebral I/R injury by middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. We randomly assigned 60 rats to three groups (20 rats per group): sham-operated, vehicle-treated I/R, and osthole-treated I/R. We treated rats intraperitoneally with osthole (40 mg/kg) or vehicle 30 min before cerebral ischemia. We harvested the brains for infarct volume, brain water content, histological changes and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining as well as cleaved caspase-3, bax, and bcl-2 levels 24 h after reperfusion.
4.[Inhibition of osthole for resorption of rats femur tissue in vitro].
Zhou J, Ren XM, Ma XN, Gao YH, Yan LJ, Shi WG, Chen KM. Zhongguo Gu Shang. 2015 Sep;28(9):832-7.
OBJECTIVE: To investigate osthole effect on femoral tissue resorption activity of rat in vitro.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Calcium Channel Products

CAS 111011-76-8 Efonidipine hydrochloride monoethanolate

Efonidipine hydrochloride monoethanolate
(CAS: 111011-76-8)

The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders.

CAS 66085-59-4 Nimodipine

(CAS: 66085-59-4)

Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intrac...

CAS 68291-97-4 Zonisamide

(CAS: 68291-97-4)

Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and r...

CAS 52468-60-7 Flunarizine

(CAS: 52468-60-7)

Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity...

CAS 63-91-2 L-phenylalanine

(CAS: 63-91-2)

L-Phenylalanine, a α-amino acid, is an antagonist at α2δ calcium channels (Ki =980 nM).

CAS 74764-40-2 Bepridil hydrochloride hydrate

Bepridil hydrochloride hydrate
(CAS: 74764-40-2)

Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the tre...

CAS 91599-74-5 Benidipine HCl

Benidipine HCl
(CAS: 91599-74-5)

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

CAS 478296-72-9 Gabapentin enacarbil

Gabapentin enacarbil
(CAS: 478296-72-9)

Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin.

CAS 1072018-68-8 TTA-P2

(CAS: 1072018-68-8)

TTA-P2 is a selective T-type calcium channel blocker. It blocks T-type currents with an IC50 of 100 nM and stabilized channel in the inactive state in rats DRGs...

CAS 1841-19-6 Fluspirilene

(CAS: 1841-19-6)

Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM). Fluspirilene is also a...

CAS 99254-95-2 McN5691

(CAS: 99254-95-2)

McN5691, an antihypertensive agent, is a voltage-sensitive calcium channel blocker.

CAS 68099-86-5 Bepridil hydrochloride

Bepridil hydrochloride
(CAS: 68099-86-5)

Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the tre...

CAS 123524-52-7 Azelnidipine

(CAS: 123524-52-7)

Azelnidipine is a dihydropyridine calcium channel blocker.

CAS 30484-77-6 Flunarizine Dihydrochloride

Flunarizine Dihydrochloride
(CAS: 30484-77-6)

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

(CAS: 187523-35-9)

Flindokalner, an anxiolytic agent, is a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Flindokalner can b...

(CAS: 1138245-13-2)

This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which...

CAS 88150-42-9 Amlodipine

(CAS: 88150-42-9)

Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

CAS 357400-13-6 NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride
(CAS: 357400-13-6)

NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)

(CAS: 170684-14-7)

UK-1745, an indole derivative, has been found to be a Calcium channel antagonist that was once studied in the treatment of arrhythmias as well as heart failure.

CAS 212778-82-0 Elpetrigine

(CAS: 212778-82-0)

Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...

Chemical Structure

CAS 484-12-8 Osthole

Quick Inquiry

Verification code

Featured Items