Oseltamivir Phosphate - CAS 204255-11-8
Catalog number: 204255-11-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Influenza Virus
Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective.
Publictions citing BOC Sciences Products
  • >> More
1. Expanding horizons of shikimic acid Recent progresses in production and its endless frontiers in application and market trends
Garima Rawat & Priyanka Tripathi & R. K. Saxena. Appl Microbiol Biotechnol (2013) 97:4277–4287
Shikimic acid also has a plethora of interesting industrial application. As discussed previously, in pharmaceuticals shikimic acid acts as starting material for the synthesis of drug Oseltamivir phosphate (Tamiflu) (Knop et al. 2001; Nie et al. 2009;Pollack 2005; Raghavendra et al. 2009;Knopetal. 2001). Current industrial synthesis of Oseltamivir phosphate (Fig. 5) has been developed by the chemists at Gilead Sciences, Inc. and F. Hoffman-La Roche. Among all the reported syntheticmethods, La Roche’smethod seems to have been the best one for industrial large-scale preparation of Tamiflu, but there are some drawbacks associated with this method like the long synthetic route and the relatively low total yield. In this context, a short and practical synthesis of Oseltamivir Phosphate (Tamiflu) from (−)-Shikimic acid has been reported (Nie et al. 2009) which constitute overall eight steps and high yield (47 %) (Fig. 5). Other merits include inexpensive reagents, mildness of the reaction conditions, and ease of manipulation of every step. Shikimic acid is also considered as a useful additive in hair growth products due to the interaction in the biochemistry of serotonin and melatonin which is recently reported to be involved in treatment of alopecia (Guglielmini 2010; Sakaguchi et al. 2004).
2. Effects of oseltamivir phosphate (Tamiflu®) in human sera on results of microneutralization and hemagglutinin-inhibition tests for H5N2 avian influenza virus
Yoshinao Yamazaki , M. Doy , S. Yamato. Y. Kawada, T. Ogata. Arch Virol (2008) 153:945–949
During this outbreak, many MNT-positive individuals were prescribed oseltamivir phosphate (OP; Tamiflu®). OP is an orally active prodrug of oseltamivir carboxylate (OC), which is particularly effective against the influenza virus neuraminidase; it is designed to target conserved residues at the neuraminidase enzyme active site of influenza A and B viruses. Koopmans et al. suggested that the prophylactic use of oseltamivir was associated with the development of anti-influenza A virus antibodies. This may be regarded as a false-positive result caused by the presence of unknown agents. Clarification of the MNT-positive results in Ibaraki as true positives or false positives is required.
3. High and continuous exposure of laninamivir, an anti-influenza drug, may work suppressively to generate low-susceptibility mutants in animals
huku Kubo • Akane Tokumitsu • Takanori Tomozawa • Masayo Kakuta • Makoto Yamashita. J Infect Chemother (2012) 18:69–74
Mice anesthetized with 2.5% isoflurane were infected intranasally on day 0 with 30 plaque-forming units/mouse of A/PR/8/34. For the laninamivir octanoate group, the anesthetized mice were intranasally administered 50 ll laninamivir octanoate at 80 lg/kg once at 9 h post infection (hpi) after one cycle replication of the infected viruses, then saline was orally administered according to the oseltamivir phosphate administration schedule. For the oseltamivir phosphate group, 200 ll oseltamivir phosphate at 1 mg/kg beginning at 9 hpi was continued twice daily for a total of ten times. For the control group, saline was both intranasally and orally administered at 9 hpi, then orally administered according to the oseltamivir phosphate administration schedule.
4. Simple and Sensitive Spectrofluorimetric Methodmfor the Determination of Oseltamivir Phosphate in Capsules Through Derivatization with Fluorescamine
Zeynep Aydoğmuş. J Fluoresc (2009) 19:673–679
Oseltamivir phosphate (OSP) (3R,4R,5S)-4-acetylamino-5-amino-3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester, phosphate (Fig. 1) is an antiviral drug used in the treatment and prophylaxis of both influenza virus A and influenza virus B. Oseltamivir phosphate (OSP) is an ethyl ester pro-drug that is rapidly and extensively metabolized by esterases in the gastrointestinal tract and liver to its active form, oseltamivir carboxylate (OSC). There are some analytical methods in the literature for the analysis of Oseltamivir phosphate (OSP) or its active metabolite, OSC in the biological fluids and pharmaceutical preparations. Three high performance liquid chromatography (HPLC) methods with fluorescence in plasma and with UV detection in human serum and in biological materials have been reported for the analysis of OSC. An enzymatic assay based on neuraminidase inhibition has also reported for analysis of OSC [8]. A liquid chromatography/mass spectrometry (LC/MS) with solid phase extraction and LC-tandem MS methods for determination of OSP and OSC in human and animal plasma, urine and saliva have been reported. Three high performance liquid chromatography (HPLC) and colorimetric methods have been reported for determination of OSP in pharmaceutical preparations. These methods offered the required sensitivity for the analysis oseltamivir in pharmaceutical dosage forms and biological fluids; however their sophisticated instrumentation and high-analysis cost limited their use for analysis of oseltamivir (OSP).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Influenza Virus Products

CAS 204255-11-8 Oseltamivir Phosphate

Oseltamivir Phosphate
(CAS: 204255-11-8)

Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective.

CAS 13392-28-4 Rimantadine

(CAS: 13392-28-4)

Rimantadine, an adamantane derivative, could be an effective antiviral drug and probably prevent influenza virus at some extent.

(CAS: 197316-54-4)

FR-198248, a new type of hydroxyl benzaldehyde compound, was isolated from the cultured broth of a fungal strain identified as Aspergillus terreus from morpholo...

CAS 665-66-7 Amantadine Hydrochloride

Amantadine Hydrochloride
(CAS: 665-66-7)

Amantadine Hydrochloride is a NMDA-receptor antagonist acts as an antiviral and an antiparkinsonian drug.

CAS 139110-80-8 Zanamivir

(CAS: 139110-80-8)

Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.

CAS 330600-85-6 Peramivir

(CAS: 330600-85-6)

Peramivir is an antiviral inhibitor, preventing viruses from infected cells with an IC50 of median 0.09 nM.

CAS 131707-23-8 Arbidol Hydrochloride

Arbidol Hydrochloride
(CAS: 131707-23-8)

Arbidol HCl is an antiviral treatment for influenza infection.

CAS 1041434-82-5 Peramivir Trihydrate

Peramivir Trihydrate
(CAS: 1041434-82-5)

Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific inf...


CEF6, one of the the CEF control peptides, is a 9-aa-long peptide corresponding to aa 418-426 of the influenza A virus (H1N1) nucleocapsid protein.

CAS 1190215-03-2 M2 ion channel blocker

M2 ion channel blocker
(CAS: 1190215-03-2)

M2 ion channel blocker is an antiviral agent that works through blocking the activity of M2 ion channel.

CAS 341001-38-5 Nucleozin

(CAS: 341001-38-5)

Nucleozin. a cell-permeable isoxazolylpiperazine, targets influenza a nucleoprotein (NP) to inhibit influenza A H1N1, H3N2 and H5N1.

CAS 1501-84-4 Rimantadine hydrochloride

Rimantadine hydrochloride
(CAS: 1501-84-4)

Rimantadine hydrochloride, also called as Flumadine, is a nucleic acid synthesis inhibitor and an anti-influenza virus drug.

CAS 3160-91-6 Moroxydine Hydrochloride

Moroxydine Hydrochloride
(CAS: 3160-91-6)

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.

CAS 187227-45-8 Oseltamivir acid

Oseltamivir acid
(CAS: 187227-45-8)

Oseltamivir acid is the active metabolite of oseltamivir. Oseltamivir, also called as GS 4071 or Ro 64-0802, is an antiviral drug that competitively inhibits ne...

(CAS: 1629869-44-8)

VX-787, a pyrrolopyridine derivative, has been found to be an antiviral agent and is still under Phase II trial against Influenza A virus infection.

Chemical Structure

CAS 204255-11-8 Oseltamivir Phosphate

Quick Inquiry

Verification code

Featured Items