Oseltamivir acid - CAS 187227-45-8
Catalog number: B0084-172019
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Influenza Virus
Oseltamivir acid is the active metabolite of oseltamivir. Oseltamivir, also called as GS 4071 or Ro 64-0802, is an antiviral drug that competitively inhibits neuraminidase A and B (IC50 = 0.1 to 4.9 nM).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-172019 50 mg $349 In stock
Bulk Inquiry
White Solid
(3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylic acid Oseltamivir acid Oseltamivir carboxylate 187227-45-8 Oseltamivir (acid) (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid (3R,4R,5S)-5-amino-4-ace
Soluble to ≥ 56 mg/mL in H2O
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -64℃ for long term (months to years).
A metabolite of Oseltamivir.
Shelf Life:
2 years
Boiling Point:
508.7±50.0 °C | Condition: Press: 760 Torr
Melting Point:
185-187 °C
1.15 g/cm3
Canonical SMILES:
1.Enhanced production of shikimic acid using a multi-gene co-expression system in Escherichia coli.
Liu XL1, Lin J2, Hu HF1, Zhou B1, Zhu BQ3. Chin J Nat Med. 2016 Apr;14(4):286-93. doi: 10.1016/S1875-5364(16)30029-2.
Shikimic acid (SA) is the key synthetic material for the chemical synthesis of Oseltamivir, which is prescribed as the front-line treatment for serious cases of influenza. Multi-gene expression vector can be used for expressing the plurality of the genes in one plasmid, so it is widely applied to increase the yield of metabolites. In the present study, on the basis of a shikimate kinase genetic defect strain Escherichia coli BL21 (ΔaroL/aroK, DE3), the key enzyme genes aroG, aroB, tktA and aroE of SA pathway were co-expressed and compared systematically by constructing a series of multi-gene expression vectors. The results showed that different gene co-expression combinations (two, three or four genes) or gene orders had different effects on the production of SA. SA production of the recombinant BL21-GBAE reached to 886.38 mg·L(-1), which was 17-fold (P < 0.05) of the parent strain BL21 (ΔaroL/aroK, DE3).
2.In silico screening of molecular imprinting prepolymerization systems: oseltamivir selective polymers through full-system molecular dynamics-based studies.
Shoravi S1, Olsson GD1, Karlsson BC1, Bexborn F1, Abghoui Y1, Hussain J1, Wiklander JG1, Nicholls IA2. Org Biomol Chem. 2016 Apr 4. [Epub ahead of print]
All-component molecular dynamics studies were used to probe a library of oseltamivir molecularly imprinted polymer prepolymerization mixtures. Polymers included one of five functional monomers (acrylamide, hydroxyethylmethacrylate, methacrylic acid, 2-(triflouromethyl)acrylic acid, 4-vinylpyridine) and one of three porogens (acetonitrile, chloroform, methanol) combined with the crosslinking agent ethylene glycol dimethacrylate and initiator 2,2'-azobis(2-methylpropionitrile). Polymers were characterized by nitrogen gas sorption measurements and SEM, and affinity studies performed using radioligand binding in various media. In agreement with the predictions made from the simulations, polymers prepared in acetonitrile using either methacrylic or trifluoromethacrylic acid demonstrated the highest affinities for oseltamivir. Further, the ensemble of interactions observed in the methanol system provided an explanation for the morphology of polymers prepared in this solvent.
Falynskova IN, Leonova EI, Fedyakina IT, Makhmudova NR, Lepekha LN, Mikhailova NA, Rasnetsov LD, Zverev VV, Leneva IA. Zh Mikrobiol Epidemiol Immunobiol. 2015 Sep-Oct;(5):32-9.
AIM: Study the effectiveness of the substance and various drug formulations of fullerene-(tris-aminocapronic acid) hydrate (FTAAH onwards) in the model of experimental viral-bacterial pneumonia of mice.
4.Novel binding patterns between ganoderic acids and neuraminidase: Insights from docking, molecular dynamics and MM/PBSA studies.
Yang Z1, Wu F2, Yuan X3, Zhang L4, Zhang S5. J Mol Graph Model. 2016 Apr;65:27-34. doi: 10.1016/j.jmgm.2016.02.006. Epub 2016 Feb 15.
Recently, ganoderic acids (GAs) give rise to the attractive candidates of novel neuraminidase (NA) inhibitors. However, there is still no evident conclusion about their binding patterns. To this end, docking, molecular dynamics and MM/PBSA methods were combined to study the binding profiles of GAs with the N1 protein and familiar H274Y and N294S mutations (A/Vietnam/1203/04 stain). It was found that the binding affinities of ganoderic acid DM and Z (ΔGbind, -16.83 and -10.99kcalmol(-1)) are comparable to that of current commercial drug oseltamivir (-23.62kcalmol(-1)). Electrostatic interaction is the main driving force, and should be one important factor to evaluate the binding quality and rational design of NA inhibitors. The 150-loop residues Asp151 and Arg152 played an important role in the binding processes. Further analysis revealed that ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Influenza Virus Products

CAS 131707-23-8 Arbidol Hydrochloride

Arbidol Hydrochloride
(CAS: 131707-23-8)

Arbidol HCl is an antiviral treatment for influenza infection.

CAS 3160-91-6 Moroxydine Hydrochloride

Moroxydine Hydrochloride
(CAS: 3160-91-6)

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.

CAS 1041434-82-5 Peramivir Trihydrate

Peramivir Trihydrate
(CAS: 1041434-82-5)

Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific inf...

CAS 341001-38-5 Nucleozin

(CAS: 341001-38-5)

Nucleozin. a cell-permeable isoxazolylpiperazine, targets influenza a nucleoprotein (NP) to inhibit influenza A H1N1, H3N2 and H5N1.

CAS 187227-45-8 Oseltamivir acid

Oseltamivir acid
(CAS: 187227-45-8)

Oseltamivir acid is the active metabolite of oseltamivir. Oseltamivir, also called as GS 4071 or Ro 64-0802, is an antiviral drug that competitively inhibits ne...

(CAS: 197316-54-4)

FR-198248, a new type of hydroxyl benzaldehyde compound, was isolated from the cultured broth of a fungal strain identified as Aspergillus terreus from morpholo...

CAS 1629869-44-8 VX-787

(CAS: 1629869-44-8)

VX-787, a pyrrolopyridine derivative, has been found to be an antiviral agent and is still under Phase II trial against Influenza A virus infection.


CEF6, one of the the CEF control peptides, is a 9-aa-long peptide corresponding to aa 418-426 of the influenza A virus (H1N1) nucleocapsid protein.

Chemical Structure

CAS 187227-45-8 Oseltamivir acid

Quick Inquiry

Verification code

Featured Items